Table 1.

Clinical and biologic characteristics of patients at baseline by tertiles of glycated hemoglobin

CharacteristicHbA1c
All PatientsFirst Tertile (<5.3%)Second Tertile (5.3%–5.6%)Third Tertile (5.7%–6.4%)P Value
Total no. of patients1165335390440
Age (yr)56.5±16.049.8±16.756.5±15.961.6±13.5<0.001
Male sex764 (65.6)216 (64.5)257 (65.9)291 (66.1)0.88
Black ethnicity140 (12.5)40 (12.4)40 (10.7)60 (14.2)0.34
Smoking status0.02
 Past smoker348 (29.9)77 (23.0)133 (34.1)138 (31.4)
 Current smoker174 (14.9)58 (17.3)54 (13.8)62 (14.1)
History of CV disease158 (13.9)31 (9.5)52 (13.6)75 (17.4)0.01
BMI (kg/m2)25.4±4.624.1±4.625.3±4.226.5±4.6<0.001
Systolic BP (mmHg)134±20132±19133±19136±200.003
Diastolic BP (mmHg)75±1275±1275±1275±120.67
ACEi or ARB treatment813 (74.7)230 (74.4)278 (76.6)305 (73.1)0.54
Statin use444 (40.8)90 (29.1)146 (40.2)208 (49.9)<0.001
ESA use64 (5.9)31 (10.0)14 (3.9)19 (4.6)0.001
mGFR (ml/min per 1.73 m2)39.6 (27.3–54.8)39.9 (26.9–59.8)41.9 (27.7–54.8)37.4 (26.9–52.0)0.10
PCR (mg/mg)0.20 (0.09–0.75)0.30 (0.10–0.88)0.19 (0.17–0.62)0.18 (0.09–0.62)0.03
Fasting plasma glucose (mg/dl)91.9±10.888.2±10.891.9±9.097.3±10.8<0.001
Hemoglobin (g/dl)12.7±1.612.7±1.912.8±1.512.7±1.60.42
Albumin (g/dl)3.98±0.454.01±0.523.98±0.433.96±0.410.11
LDL cholesterol (mg/dl)116.2±38.2116.2±40.9115.4±37.1116.2±37.10.94
Triglycerides (mg/dl)129.2±84.1124.8±79.6134.5±85.0127.4±86.70.12
Uric acid (mg/dl)6.99±1.806.84±1.706.88±1.777.21±1.880.004
Nephropathy type<0.001
 Glomerular219 (18.8)76 (22.7)84 (21.5)59 (13.4)
 Vascular315 (27.0)73 (21.8)106 (27.2)136 (30.9)
 Polycystic kidney disease88 (7.6)30 (9.0)27 (6.9)31 (7.0)
 Intersitial127 (10.9)50 (14.9)35 (9.0)42 (9.5)
 Other416 (35.7)106 (31.6)138 (35.4)172 (39.1)
  • Data are expressed as mean±SD, median (interquartile range), n (%), or as otherwise indicated. CV, cardiovascular; BMI, body mass index; ACEi, angiotensin-converting enzyme inhibitor; ARB, antireceptor blocker; ESA, erythropoiesis-stimulating agents; mGFR, measured GFR; PCR, proteinuria/creatininuria ratio; HbA1c, glycated hemoglobin.