Table 4.

Comparison of the estimated association of induction treatments on overall allograft failure through the end of the follow-up using multivariable Cox regression models

Multivariable ModelInduction TypeHR (95% CI)P Value
Steroid
 Cox regression
IL-2 RA1
r-ATG1.00 (0.91 to 1.09)0.93
No induction1.00 (0.91 to 1.09)0.92
 PS-weighted Cox regression
IL-2 RA1
r-ATG0.99 (0.91 to 1.08)0.79
No induction0.99 (0.90 to 1.08)0.76
No Steroid
 Cox regression
IL-2 RA1
r-ATG1.14 (0.93 to 1.39)0.21
Alemtuzumab1.21 (0.98 to 1.49)0.07
 PS-weighted Cox regression
IL-2 RA1
r-ATG1.19 (0.97 to 1.45)0.01
Alemtuzumab1.27 (1.03 to 1.56)0.02
  • Adjusted for donor factors (age, sex, and race), recipient factors (age, sex, race, cardiovascular morbidity, panel reactive antibody, retransplant status, and dialysis status) and transplant factors (donor/recipient weight ratio, HLA mismatch, and transplant year). PS, propensity score; IL2-RA, IL-2 receptor antagonist; r-ATG, rabbit anti-thymocyte globulin; HR, hazard ratio; 95% CI, 95% confidence interval.