Table 2.

Unadjusted and adjusted hazard ratios for ESRD in the overall population

Variable (per IQR Changea)UnadjustedAdjusted
HR (95% CI)P ValueHR (95% CI)P Value
Factor VIIc1.85 (1.56 to 2.18)<0.0011.46 (1.21 to 1.76)<0.001
Factor VIIIc2.12 (1.81 to 2.49)<0.0011.20 (1.00 to 1.44)0.02
Fibrinogen1.93 (1.66 to 2.24)<0.0011.35 (1.15 to 1.60)<0.001
von Willebrand factor2.18 (1.81 to 2.62)<0.0011.29 (1.06 to 1.56)0.01
Protein C1.17 (1.01 to 1.36)0.041.19 (1.00 to 1.42)0.03
Antithrombin III1.19 (1.00 to 1.41)0.051.07 (0.90 to 1.27)0.43
  • Adjusted analysis covariates included age, ancestry-center-APOL1 risk status, sex, systolic BP, diabetes status, hypertension medication use, prevalent coronary heart disease, smoking status, log-transformed triglycerides, HDL cholesterol, log-transformed LDL cholesterol, year of marker measurement, baseline eGFR, use of salicylates, hematocrit, log-transformed platelet count, log-transformed white blood cell count, and serum albumin. IQR, interquartile range; HR, hazard ratio; 95% CI, 95% confidence interval.

  • a The HRs and 95% CIs were estimated using log-transformed hemostatic factor for one IQR.