Table 4.

Cox proportional hazard ratios for hospitalization for AKI for urate and genetic urate score, overall and by subgroup

GroupPlasma Urate, per 1 mg/dlaGenetic Urate Score, per 1 mg/dlb
Participants (n)Urate ≤5.0 mg/dlUrate >5.0 mg/dlP Value for InteractionParticipants (n)aHR (95% CI)P Value
aHR (95% CI)P ValueaHR (95% CI)P Value
All participants11,0111.10 (0.92 to 1.30)0.301.16 (1.10 to 1.23)<0.001N/A75331.01 (0.77 to 1.34)0.92
eGFR0.55
 ≥60 ml/min per 1.73 m210,3351.07 (0.90 to 1.29)0.431.17 (1.10 to 1.26)<0.00170630.98 (0.72 to 1.32)0.87
 <60 ml/min per 1.73 m26761.31 (0.64 to 2.72)0.451.11 (0.99 to 1.25)0.084701.20 (0.64 to 2.26)0.57
Proteinuria0.88
 ACR<30 mg/g10,1071.13 (0.93 to 1.37)0.221.15 (1.07 to 1.23)<0.00170320.95 (0.70 to 1.30)0.76
 ACR≥30 mg/g9040.92 (0.62 to 1.37)0.671.18 (1.05 to 1.33)0.0075011.13 (0.57 to 2.27)0.72
CKDc0.92
 No96081.10 (0.90 to 1.34)0.341.15 (1.06 to 1.24)<0.00166620.89 (0.64 to 1.23)0.48
 Yes14031.05 (0.74 to 1.50)0.791.16 (1.06 to 1.28)0.0018711.24 (0.75 to 2.06)0.40
Gout status0.02
 No gout10,2911.06 (0.89 to 1.27)0.521.23 (1.15 to 1.31)<0.00170950.96 (0.72 to 1.29)0.81
 Gout6541.14 (0.52 to 2.51)0.741.00 (0.86 to 1.15)0.964110.88 (0.36 to 2.11)0.77
  • aHR, adjusted hazard ratio; 95% CI, 95% confidence interval; N/A, not applicable; ACR, albumin-to-creatinine ratio.

  • a Adjusted for age, sex, race, hypertension, diabetes, coronary heart disease, eGFR, logACR, diuretic use, allopurinol use, losartan use. Urate is modeled as a linear spline with knot at 5 mg/dl.

  • b Adjusted for age, sex, and study center.

  • c eGFR<60 ml/min per 1.73 m2 or eGFR≥60 ml/min per 1.73 m2 with ACR≥30 mg/g.