Table 1.

Baseline characteristics of participants by quartiles of plasma urate

CharacteristicQuartile 1 (n=2993)Quartile 2 (n=2674)Quartile 3 (n=2654)Quartile 4 (n=2690)P Value for Trend
Mean urate±SD (range) (mg/dl)3.9±0.6 (1.5–4.6)5.1±0.3 (4.7–5.5)6.0±0.3 (5.6–6.5)7.6±1.0 (6.6–14.4)N/A
Mean age±SD (yr)62.9±5.863.2±5.663.3±5.663.8±5.7<0.001
Men (%)20.940.354.063.8<0.001
Black (%)19.420.420.827.0<0.001
Diabetes (%)15.516.016.119.4<0.001
Hypertension (%)37.344.547.460.7<0.001
Prevalent coronary heart disease (%)4.67.78.213.6<0.001
Mean eGFR±SD (ml/min per 1.73 m2)91.1±13.487.6±14.385.7±15.080.4±18.5<0.001
eGFR<60 ml/min per 1.73 m2 (%)2.13.65.214.1<0.001
ACR≥30 mg/g (%)6.57.17.511.9<0.001
Diuretic use (%)8.112.416.832.6<0.001
Allopurinol use (%)1.11.41.42.3<0.001
Losartan use (%)0.40.90.50.80.12
Gout (%)2.84.04.712.8<0.001
  • Participant numbers in quartiles are not identical because of large numbers of participants with the same urate level. N/A, not applicable; ACR, albumin-to-creatinine ratio.