Table 3.

Baseline characteristics of participants by quartiles of genetic urate score

CharacteristicQuartile 1 (n=1884)Quartile 2 (n=1883)Quartile 3 (n=1883)Quartile 4 (n=1883)P Value for Trend
Mean urate±SD (range) (mg/dl)5.2±1.4 (1.5–11.1)5.5±1.4 (1.6–11.1)5.6±1.4 (1.8–13.0)6.0±1.5 (1.5–12.3)<0.001
Mean age±SD (yr)63.7±5.663.6±5.663.5±5.763.5±5.60.22
Men (%)48.046.646.544.90.07
Diabetes (%)15.313.313.112.80.03
Hypertension (%)41.842.742.541.80.99
Prior coronary heart disease (%)8.89.08.88.40.63
Mean eGFR±SD (ml/min per 1.73 m2)84.4±14.184.3±14.285.5±14.184.6±14.50.23
eGFR<60 ml/min per 1.73 m2 (%)5.76.32.42.50.19
ACR≥30 mg/g (%)6.16.57.56.50.37
Diuretic use (%)13.915.414.415.70.21
Allopurinol use (%)0.61.11.52.8<0.001
Losartan use (%)0.50.51.10.80.09
Gout (%)3.43.96.28.4<0.001
  • Race is not included as a covariate because genetic urate score was available for white participants. ACR, albumin-to-creatinine ratio.