Table 3.

Estimated declines in GFR by combined baseline urinary protein-to-creatinine ratio and BP status

Baseline Up/cNormotensive (BP < 90th Percentile) (n=358)Elevated BP (BP ≥90th Percentile) (n=164)
Patients (n)Median (IQR) Baseline GFR (ml/min per 1.73 m2)Mean Change in GFR (ml/min per 1.73 m2 per yr) (95% CI)aPatients (n)Median (IQR) Baseline GFR (ml/min per 1.73 m2)Mean Change in GFR (ml/min per 1.73 m2 per yr) (95% CI)a
<0.522953 (42, 69)−0.8 (−1.2 to −0.4)9458 (44, 71)−1.9 (−2.5 to −1.2)
≥0.512939 (29, 51)−1.8 (−2.4 to −1.2)7040 (30, 49)−1.7 (−2.4 to −1.0)
 P value for difference<0.001b0.01a<0.001b0.77a
  • Test for heterogeneity of association between baselineUp/c and GFR change by BP status: P=0.08.95% CI.

  • a Estimates of change in GFR and reported P values derived from multivariable linear mixed-effects model adjusting for baseline Up/c, baseline BP status, baseline age, sex, race, current BMI z-score, and current angiotensin-converting enzyme inhibitor/angiotensin-receptor blocker use.

  • b Derived from Wilcoxon rank-sum test.