Table 1.

Baseline characteristics by age group and by treatment arm

CharacteristicAge <65 yr (n=2878)Age ≥65 yr (n=1005)
Cinacalcet 
(N1=1418)Placebo
(N1=1460)Cinacalcet
(N1=530)Placebo
(N1=475)
Age (yr)a50 (32, 61)50 (33, 61)71 (66, 80)71 (66, 80)
Womenb569 (40)574 (39)240 (45)195 (41)
Race or ethnic groupa
 White771 (54)785 (54)353 (67)331 (70)
 Black321 (23)341 (23)88 (17)87 (18)
 Other326 (23)334 (23)89 (17)57 (12)
Regiona
 United States520 (37)534 (37)195 (37)181 (38)
 Europe387 (27)407 (28)211 (40)183 (39)
 Latin America292 (21)302 (21)53 (10)40 (8)
 Russia128 (9)126 (9)15 (3)14 (3)
 Australia43 (3)45 (3)31 (6)30 (6)
 Canada48 (3)46 (3)25 (5)27 (6)
Dialysis vintage (mo)a47 (9, 156)48 (11, 159)40 (7, 106)39 (9, 116)
Current dialysis accessa
 Fistula1062 (75)1073 (74)363 (69)317 (67)
 Graft172 (12)205 (14)75 (14)78 (16)
 Permanent catheter151 (11)155 (11)80 (15)67 (14)
 Other33 (2)27 (2)12 (2)13 (3)
BP (mmHg)
 Systolic140 (111, 177)140 (111, 178)140 (110, 175)141 (111, 175)
 Diastolica80 (60, 100)80 (63, 100)72 (56, 89)73 (60, 89)
Tobacco usea
 Never774 (55)829 (57)312 (59)269 (57)
 Current279 (20)289 (20)33 (6)31 (7)
 Former363 (26)341 (23)185 (35)175 (37)
Diabetesa414 (29)422 (29)240 (45)226 (48)
Heart failurea281 (20)294 (20)169 (32)162 (34)
Peripheral vascular diseasea181 (13)194 (13)132 (25)128 (27)
Coronary artery bypass grafta58 (4)68 (5)77 (15)86 (18)
Percutaneous coronary interventiona79 (6)81 (6)51 (10)51 (11)
Myocardial infarctiona138 (10)132 (9)101 (19)112 (24)
Strokea99 (7)132 (9)63 (12)61 (13)
Transient ischemic attacka54 (4)40 (3)46 (9)34 (7)
Amputation86 (6)89 (6)35 (7)40 (8)
Atrial fibrillationa82 (6)109 (8)120 (23)116 (24)
Parathyroidectomyc79 (6)71 (5)12 (2)16 (3)
Fracture265 (19)292 (20)117 (22)95 (20)
iPTH (pg/ml)a732 (373, 1756)747 (379, 1799)608 (338, 1565)580 (322, 1316)
Corrected serum calcium (mg/dl)a9.7 (9.0, 10.7)9.8 (9.0, 10.7)9.9 (9.1, 10.8)9.9 (9.1, 10.8)
Serum phosphorus (mg/dl)a6.4 (5.1, 8.5)6.4 (5.0, 8.6)5.9 (4.8, 7.8)5.7 (4.7, 7.7)b
Serum total alkaline phosphatases (μg/L)a111 (66, 259)110 (65, 246)98 (63, 214)105 (65, 193)
Serum bone alkaline phosphatases ≥21 (μg/L)a820 (58)811 (56)247 (47)232 (49)
Serum albumin (g/dl)a3.7 (3.2, 4.1)3.7 (3.2, 4.1)3.6 (3.1, 4.0)3.6 (3.1, 4.0)
Medication use821 (56)832 (57)335 (63)322 (68)
 Vitamin D sterola770 (54)795 (55)267 (50)230 (48)
 Calcium-containing phosphate binderc484 (34)514 (35)190 (36)183 (39)
 Noncalcium-containing phosphate binder
 β-adrenergic antagonists690 (49)669 (46)255 (48)209 (44)
 RAS inhibitors651 (46)633 (43)222 (42)194 (41)
 Antiplatelet agentsa455 (32)489 (34)279 (53)247 (52)
 Statinsa395 (28)400 (27)252 (48)214 (45)
  • Data are presented as the median (10th and 90th percentiles) or n (%) unless otherwise indicated. Percentages are based on N1. Significance of the differences between each age group, combining those randomized to placebo and to cinacalcet, are indicated by lettered footnotes. iPTH, intact parathyroid hormone; RAS, renin-angiotensin system.

  • a P value <0.001.

  • b P value <0.05.

  • c P value <0.01.