Table 2.

Results of univariable and multivariable mixed-effects linear models of GFR on baseline exposures of interest (n=522 children with nonglomerular CKD; 2101 person-visits)

ParameterEstimate (95% CI)
UnivariateBaseline Up/c OnlyBaseline SBP z-Score OnlyBaseline DBP z-Score OnlyMultivariablea
Expected baseline GFR (ml/min per 1.73 m2)
 Interceptb52.1 (50.4 to 53.8)54.0 (52.5 to 55.5)52.0 (50.2 to 53.8)51.8 (49.8 to 53.9)53.3 (50.7 to 56.0)
 Per 2-fold larger baseline Up/c−5.5 (−6.3 to −4.7)−5.5 (−6.3 to −4.7)
 Per 1-unit larger baseline SBP z-score0.3 (−1.3 to 1.8)−0.2 (−1.8 to 1.4)
 Per 1-unit larger baseline DBP z-score0.5 (−1.4 to 2.3)0.8 (−1.1 to 2.8)
Expected GFR change per yr (ml/min per 1.73 m2 per yr)
 Reference groupc−1.3 (−1.6 to −1.1)−1.3 (−1.6 to −1.0)−1.2 (−1.5 to −0.9)−1.2 (−1.5 to −0.8)−1.1 (−1.5 to −0.8)
 Per 2-fold larger baseline Up/c−0.3 (−0.5 to −0.1)−0.3 (−0.4 to −0.1)
 Per 1-unit larger baseline SBP z-score−0.4 (−0.7 to −0.1)−0.4 (−0.7 to −0.1)
 Per 1-unit larger baseline DBP z-score−0.3 (−0.6 to 0.0)0.0 (−0.3 to 0.4)
  • CI, confidence interval; Up/c, urinary protein-to-creatinine ratio; SBP, systolic BP; DBP, diastolic BP.

  • a Multivariable model adjusted for variables shown in table, as well as sex, race, baseline age, current body mass index z-score, and current angiotensin-enzyme inhibitor/angiotensin-receptor blocker use.

  • b For models including Up/c, this is the expected baseline GFR for children with Up/c of 0.25 mg/mg; for models with SBP z-score and DBP z-score, this is the expected baseline GFR for children with SBP and DBP, respectively, at the 50th percentile for age, sex, and height.

  • c For models including Up/c, this is the expected 1-year change in GFR for children with Up/c of 0.25 mg/mg; for models with SBP z-score and DBP z-score, this is the expected 1-year change in GFR for children with SBP and DBP, respectively, at the 50th percentile for age, sex, and height.