Table 2.

Key characteristics according to histopathologic diagnosis sorted by patient age at time of biopsy

Histopathologic DiagnosisNo. of Patients N (%)Genetic cause N/Ninfo (%)At First BiopsyIIT ResponsivenessESRD at Last Observation (%)
Agea (yr)Serum Albumin (g/dl)Hypertension (%)eGFRa (ml/min per 1.73 m2)Partial Remission N/Ninfo (%)Complete Remission N/Ninfo (%)
CNS8 (0.6)3/7 (43.0)0.2 (0.2–0.7)1.4 (0.4)0.056 (29–98)0/1 (0.0)0/1 (0.0)57.1
DMS39 (2.9)22/35 (62.9)1.3 (0.6–2.3)2.0 (0.8)26.359 (37–97)0/10 (0.0)1/10 (10.0)72.2
MCN283 (21.1)24/195 (12.3)4.2 (2.4–7.6)2.5 (1.0)15.8108 (86–155)41/202 (20.3)103/202 (51.0)12.9
MesPGN166 (12.4)23/123 (18.7)4.4 (2.4–8.4)2.4 (1.0)15.1118 (84–162)26/101 (25.7)41/101 (40.6)18.9
FSGS752 (56.0)122/555 (22.0)6.2 (3.0–11.0)2.7 (1.0)18.997 (68–142)93/469 (19.8)183/469 (39.0)30.9
GGS17 (1.3)4/12 (33.3)6.6 (3.4–9.1)2.8 (0.8)17.717 (10–85)0/3 (0.0)1/3 (33.3)68.8
MN11 (0.8)0/11 (0.0)7.0 (2.7–13.6)2.4 (0.9)27.3116 (103–138)3/10 (30.0)5/10 (50.0)9.1
MPGN35 (2.6)4/25 (16.0)10.5 (5.8–11.9)2.9 (0.8)22.9112 (61–148)4/16 (25.0)6/16 (37.5)23.5
Other31 (2.3)9/27 (33.3)8.8 (3.2–11.7)2.7 (1.1)6.745 (29–98)4/16 (25.0)6/16 (37.5)24.1
  • Information on genetic disease, features at first biopsy, IIT responsiveness, and fraction of ESRD at last observations refers to diagnosis by initial biopsy. Data are given as number (%), mean (SD), or median (interquartile range). CNS, Finnish-type congenital nephrotic syndrome; DMS, diffuse mesangial sclerosis; MCN, minimal change nephropathy; MesPGN, mesangioproliferative GN; GGS, global glomerulosclerosis; MN, membranous nephropathy; MPGN, membranoproliferative GN; Ninfo, number of patients with reported information.

  • a Median (interquartile range).