Table 1.

Baseline characteristics of development and validation cohorts for predicting 5-year mortality risk in community-dwelling adults with renal disease

Participant CharacteristicCardiovascular Health StudyHealth, Aging, and Body Composition StudyP Value
Number of participants828789
Demographics
 Age (yr)±SD79.9±5.674.1±2.8<0.001
 Women, n459 (55%)394 (50%)0.04
 Black race, n146 (18%)287 (36%)<0.001
Prevalent cardiovascular disease, n
 History of coronary heart disease273 (33%)194 (25%)<0.001
 History of heart failure144 (17%)41 (5%)<0.001
 History of stroke79 (10%)86 (11%)0.50
 History of any cardiovascular disease349 (42%)247 (31%)<0.001
Cardiovascular disease risk factors
 Hypertension, n597 (72%)580 (74%)0.40
 Systolic blood pressure (mmHg)±SD138±22138±22>0.99
 Use of hypertension medications, n615 (74%)502 (64%)<0.001
 Diabetes, n140 (17%)185 (23%)0.003
 Smoking, n
  Never391 (47%)364 (46%)0.70
  Former385 (46%)365 (46%)>0.99
  Current52 (6%)60 (8%)0.10
 Body mass index (kg/m2)±SD27.1±4.727.8±4.70.003
 Weight (lb)±SD160.4±31.5169.4±32.3<0.001
 Total cholesterol (mg/dl)±SD203±43204±410.60
 Serum albumin (g/dl)±SD3.83±0.303.99±0.33<0.001
 Serum albumin ≤3.70 g/dl, n259 (31%)174 (22%)<0.001
 Use of lipid-lowering medications, n115 (14%)133 (17%)0.10
Kidney function
 eGFR (ml/min per 1.73 m2)±SD47±1150±9<0.001
 Urine albumin-to-creatinine ratio (mg/g), median [interquartile range]13 [6–51]13 [6–42]0.02
 Urine albumin-to-creatinine ratio>30 mg/g, n253 (31%)199 (25%)<0.01