Table 1.

Characteristics of the study population by baseline N-terminal pro–B-type natriuretic peptide concentration (n=3752)

CharacteristicN-Terminal Pro–B-Type Natriuretic Peptide Quartiles (pg/ml)
All≤5859–115116–237>237
Number of participants3752961985959847
Demographics
 Age (yr) (SD)72 (5)70 (4)71 (5)73 (5)75 (6)
 Women, n (%)2351 (63)540 (56)662 (67)637 (66)512 (60)
 Black race, n (%)657 (18)217 (23)174 (18)145 (15)121 (14)
Prevalent cardiovascular disease, n (%)
 History of coronary heart disease679 (18)103 (11)123 (13)183 (19)270 (32)
 History of stroke134 (4)18 (2)28 (3)35 (4)53 (6)
 History of cardiovascular disease777 (21)117 (12)144 (15)210 (22)306 (36)
 Left ventricular hypertrophy (electrocardiogram Cornell volt)199 (5)27 (3)34 (4)39 (4)99 (12)
Cardiovascular disease risk factors
 Hypertension, n (%)2254 (60)504 (52)531 (54)592 (62)627 (74)
 Systolic BP (mmHg) (SD)137 (22)132 (19)134 (20)137 (21)145 (24)
 Diastolic BP (mmHg) (SD)71 (11)71 (11)71 (10)70 (12)72 (12)
 Hypertension medications, n (%)1779 (48)396 (41)413 (42)466 (49)504 (60)
 ACE inhibitors, n (%)251 (7)71 (7)56 (6)59 (6)65 (8)
 Diuretics, n (%)1048 (28)245 (26)242 (25)270 (28)291 (34)
 Diabetes, n (%)654 (17)203 (21)150 (15)152 (16)149 (18)
 Smoking, n (%)
  Never1784 (48)416 (43)478 (49)475 (50)415 (49)
  Former1533 (41)419 (44)398 (40)383 (40)333 (39)
  Current431 (12)125 (13)108 (11)100 (10)98 (12)
 Body mass index (kg/m2) (SD)26.8 (4.8)27.7 (4.7)26.9 (4.7)26.5 (4.8)26.0 (4.7)
 Total cholesterol (mg/dl) (SD)213 (39)217 (39)216 (37)211 (38)207 (42)
 LDL cholesterol (mg/dl) (SD)131 (35)134 (35)133 (34)128 (34)127 (37)
 HDL cholesterol (mg/dl) (SD)55 (16)54 (15)56 (16)56 (17)54 (16)
 Triglycerides (mg/dl), median [interquartile range]120 [92–164]128 [94–175]122 [95–165]118 [91–160]116 [87–155]
 Troponin (pg/ml), median [interquartile range]5.01 [2.99–9.64]3.12 [2.99–6.95]3.53 [2.99–7.67]5.43 [2.99–9.41]9.45 [5.01–16.08]
Kidney function
 eGFRa (ml/min per 1.73 m2) (SD)72 (19)79 (17)75 (17)71 (18)62 (19)
 Cystatin C (mg/L) (SD)1.05 (0.33)0.95 (0.20)0.99 (0.21)1.05 (0.29)1.21 (0.51)
  • a eGFR cystatin C (Chronic Kidney Disease Epidemiology Collaboration). ACE, angiotensin converting enzyme.