Table 3.

Concordance correlation coefficient, 10% accuracy, and 30% accuracy of the six eGFR formulas (compared with mGFR) in the whole cohort and bias in the three CKD subgroups.

VariablePCr-Based EquationsCystC-Based EquationsCombined PCr-CystC to Based Equations
Bedside SchwartzSchwartz–LyonHoekFillerCKiD 2012Zappitelli
All measurements (n=199) mGFR=64.3±20.8 ml/min per 1.73 m2
 eGFR (ml/min per 1.73 m2)69.8±22.5a65.0±21.857.8±17.4a69.0±21.6a62.5±16.873.4±24.7a
 CCC 0.81 (0.68 to 0.89)0.85 (0.80 to 0.88)b 0.72 (0.65 to 0.77)0.75 (0.68 to 0.80)0.85 (0.81 to 0.88)b0.79 (0.74 to 0.83)
 10% accuracy 38 (31 to 46)44 (36 to 53)34 (28 to 41)32 (26 to 39)47 (40 to 58)35 (28 to 43)
 30% accuracy 92 (85 to 95)97 (94 to 98)85 (78 to 89)82 (75 to 87)98 (96 to 99)85 (77 to 90)
GFR ≥ 90 ml/min/1.73 m2 (n=23) mGFR=102.2±12.4 ml/min per 1.73 m2
 eGFR (ml/min per 1.73 m2)101.7±19.996.7±19.179.2±13.7a95.9±14.586.8±14.4a109.8±17.4
 Bias±SD−0.5±17.2−5.4±16.5−22.9±13.4−6.3±17.3−5.9±12.17.6±17.8
 10% accuracy56 (32 to 72)52 (19 to 84)17 (2 to 33)34 (15 to 54)35 (15 to 54)48 (27 to 68)
 30% accuracy91 (80 to 99)86 (73 to 100)69 (50 to 88)50 (29 to 70)91 (79 to 98)96 (87 to 100)
60≥GFR<90 ml/min per 1.73 m2 (n=91) mGFR=71.8±8.7 mL/min/1.73 m2
 eGFR (ml/min per 1.73 m2)78.6±15.7a73.5±15.563.6±12.6a76.1±15.8a69.1±10.682.3±16.3a
 Bias±SD6.7±12.81.7±12.8b−8.2±10.74.3±14.5−2.7±8.1b10.5±14.3
 10% accuracy42 (31 to 51)46 (36 to 56)38 (28 to 48)37 (27 to 47)51 (41 to 62)39 (29 to 50)
 30% accuracy87 (79 to 93)93 (88 to 98)88 (81 to 95)90 (84 to 96)100 (100 to 100)83 (76 to 91)
GFR< 60 ml/min per 1.73 m2 (n=85) mGFR=46.0±8.7 ml/min per 1.73 m2
 eGFR (ml/min per 1.73 m2)51.7±12.7a47.3±11.045.8±13.754.2±16.7a48.7±10.154.0±15.5a
 Bias±SD5.7±9.41.3±8.2c−0.2±11.7c8.2±14.52.7±7.6c 8.0±11.8
 10% accuracy29 (19 to 39)43 (33 to 54)35 (25 to 45)26 (16 to 35)45 (34 to 55)29 (20 to 39)
 30% accuracy 81 (73 to 89)91 (86 to 98)82 (74 to 90)66 (56 to 76)90 (84 to 97)76 (67 to 85)
  • Unless otherwise noted results are expressed as mean±SD. Values expressed in parentheses are 95% confidence intervals. CCC, concordance correlation coefficient.

  • a P<0.05 between mGFR and eGFR.

  • b P<0.05 for the difference between CKiD formula and other equations (without difference with Schwartz–Lyon formula).

  • c P<0.05 for the difference between CKiD formula and other equations (without difference with Schwartz–Lyon and Hoek formulas).