Table 4.

Markers of kidney function in autochthonous villagers and Bosnian immigrants who settled EN villages 15–30 years ago

Laboratory ParameterEndemic Villages (n=1687)Control Nonendemic Villages (n=372)Bosnian Immigrants (n=102)P value
α-1CR, mg/g5.98 (3.75–10.53)7.39 (4.74–12.47)a7.04 (4.66–11.17)<0.001
α-1CR>31.5 mg/g, N (%)82 (7.3)10 (0.3)a1 (1.3)a0.003
ACR, mg/g5.29 (3.51–10.68)5.68 (3.87–10.61)5.58 (3.95–9.64)0.30
ACR>30 mg/g, N (%)189 (15.8)38 (11.4)a7 (6.7)a0.05
Serum creatinine, mg/dl1.09 (0.97–1.25)1.05a (0.94–1.21)0.98 (0.9–1.12)a,b<0.001
eGFR, ml/min per 1.73 m280 (67–94)81 (70–92)88 (73–100)a,b0.003
eGFR<60 ml/min per 1.73 m2, N (%)280 (16.6)34 (9.1)a7 (6.9)a<0.001
Hemoglobin, g/dl13.7 (12.9–14.7)14 (13–14.8)13.8 (13–14.7)0.13
Urine specific gravity1.015 (1.010–1.021)1.015 (1.010–1.020)1.016 (1.011–1.022)0.22
Left kidney length, mm109 (100–117)113 (108–119)a112 (103–120)<0.001
Right kidney length, mm109 (101–117)114 (106–120)a114 (102–118)<0.001
  • Values are expressed as medians and interquartile ranges (25th–75th). α-1CR, α-1 microglobulin level corrected for urine creatinine; ACR, urine albumine to urine creatinine ratio.

  • a Significant difference (P<0.05) with endemic villages group.

  • b Significant difference (P<0.05) with control nonendemic villages group.