Table 6.

Combined association of N-terminal pro–B-type natriuretic peptide and troponin T with rapid kidney function decline and incident CKD

TnT/NT-proBNP≥30% Decline in eGFRIncident CKD
Mean (SD) Rate (%/yr)HR (95% CI)Mean (SD) Rate (%/yr)HR (95% CI)
NT-proBNP≤237; TnT≤10.58 (n=2453)1.70 (0.13)1.00 (reference)3.38 (0.18)1.00 (reference)
NT-proBNP≤237; TnT>10.58 (n=452)2.56 (0.45)1.30 (0.98 to 1.72)5.35 (0.67)1.18 (0.92 to 1.50)
NT-proBNP>237; TnT≤10.58 (n=480)2.69 (0.42)1.45 (1.12 to 1.88)a5.13 (0.59)1.13 (0.90 to 1.42)
NT-proBNP>237; TnT>10.58 (n=367)3.74 (0.73)2.00 (1.48 to 2.71)a5.31 (1.17)0.97 (0.69 to 1.36)
  • Adjusted for age, sex, race, baseline eGFR, body mass index, diastolic BP, systolic BP, hypertension medications, diabetes mellitus, and prevalent cardiovascular disease. TnT, troponin T; HR, hazard ratio; 95% CI, 95% confidence interval.

  • a P<0.05.