Table 4.

Association between baseline N-terminal pro–B-type natriuretic peptide and decline of kidney function in community-dwelling older adults

NT-proBNP Quartiles (pg/ml)Hazard Ratio (95% Confidence Interval) for ≥30% Decline (n=3752)Hazard Ratio (95% Confidence Interval) for Incident CKD (n=2786)a
N (%)Adjusted for Demographics and Baseline eGFRAdjusted for Demographics, Baseline eGFR, and ConfoundersbAdjusted for Demographics, Baseline eGFR, Confounders,b and Troponin TAdjusted for Demographics, Baseline eGFR, Confounders,b and Interim HF or MIN (%)Adjusted for Demographics and Baseline eGFRAdjusted for Demographics, Baseline eGFR, and ConfoundersbAdjusted for Demographics, Baseline eGFR, Confounders,b and Troponin TAdjusted for Demographics, Baseline eGFR, Confounders,b and Interim HF or MI
≤58101 (12)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)157 (21)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
59–115108 (12)1.01 (0.77 to 1.33)1.06 (0.80 to 1.40)1.03 (0.78 to 1.35)1.05 (0.79 to 1.38)195 (28)1.15 (0.93 to 1.42)1.20 (0.97 to 1.49)1.21 (0.97 to 1.50)1.18 (0.96 to 1.47)
116–237115 (15)1.08 (0.82 to 1.42)1.12 (0.85 to 1.48)1.07 (0.81 to 1.41)1.10 (0.83 to 1.45)191 (33)1.27 (1.03 to 1.47)c1.29 (1.04 to 1.61)c1.30 (1.04 to 1.61)c1.29 (1.04 to 1.60)c
>237150 (25)1.73 (1.32 to 2.28)c1.67 (1.25 to 2.23)c1.51 (1.12 to 2.03)c1.56 (1.17 to 2.08)c142 (41)1.34 (1.05 to 1.69)c1.38 (1.08 to 1.76)c1.39 (1.08 to 1.79)c1.33 (1.04 to 1.70)c
  • NT-proBNP, N-terminal pro–B-type natriuretic peptide; HF, heart failure; MI, myocardial infarction.

  • a Incident CKD defined as at least a 1-ml/min per 1.73 m2 decline in eGFR per year in follow-up and eGFR<60 ml/min per 1.73 m2 at a follow-up visit.

  • b Additionally adjusted for body mass index, diastolic BP, systolic BP, hypertension medications, diabetes mellitus, and prevalent cardiovascular disease.

  • c P<0.05.