Table 3.

End points according to quartiles of serum amyloid A (HDL)

End PointsSAA(HDL) Quartile 1SAA(HDL) Quartile 2SAA(HDL) Quartile 3SAA(HDL) Quartile 4P value (chi square)
No.HRNo.HR (95% CI)No.HR (95% CI)No.HR (95% CI)
Combined primary end point1101.00 (reference)1261.22 (0.94 to 1.58)1291.31 (1.02 to 1.70)1341.25 (0.96 to 1.63)0.18
Death from cardiac causes591.00 (reference)571.03 (0.71 to 1.48)581.06 (0.73 to 1.53)721.28 (0.90 to 1.82)0.51
Sudden cardiac death361.00 (reference)300.87 (0.53 to 1.42)351.06 (0.66 to 1.70)451.42 (0.90 to 2.23)0.20
Nonfatal myocardial infarction331.00 (reference)411.42 (0.89 to 2.25)431.60 (1.01 to 2.53)341.27 (0.77 to 2.08)0.24
Fatal stroke61.00 (reference)101.74 (0.62 to 4.85)71.17 (0.39 to 3.52)111.42 (0.66 to 3.06)0.72
Nonfatal stroke121.00 (reference)181.47 (0.71 to 3.06)211.71 (0.84 to 3.49)171.42 (0.66 to 3.06)0.53
All cardiac events combined1221.00 (reference)1341.22 (0.95 to 1.56)1321.28 (0.10 to 1.64)1461.43 (1.12 to 1.82)0.04
All cerebrovascular events combined391.00 (reference)350.86 (0.54 to 1.36)431.10 (0.71 to 1.70)441.38 (0.89 to 2.13)0.21
Stroke181.00 (reference)281.57 (0.87 to 2.85)281.55 (0.85 to 2.80)281.47 (0.80 to 2.71)0.44
Death (all causes)1301.00 (reference)1180.97 (0.75 to 1.27)1411.15 (0.90 to 1.47)1751.22 (0.95 to 1.57)0.21
Death (noncardiovascular disease causes)651.00 (reference)510.86 (0.60 to 1.24)761.24 (0.89 to 1.73)921.45 (1.04 to 2.03)0.02
  • P value of multivariate Cox regression model comparing the hazard ratios across the four groups. Risk factors included in the multivariate regression model were age, sex, phosphate, use of calcium antagonists, history of coronary artery disease, arrhythmia, congestive heart failure, peripheral vascular disease, and atorvastatin treatment. SAA, serum amyloid A; HR, hazard ratio; 95% CI, 95% confidence interval.