Table 4.

End points according to quartiles of surfactant protein B (HDL)

End PointsSP-B(HDL) Quartile 1SP-B(HDL) Quartile 2SP-B(HDL) Quartile 3SP-B(HDL) Quartile 4P value (chi square)
No.HRNo.HR (95% CI)No.HR (95% CI)No.HR (95% CI)
Combined primary end point1201.00 (reference)1171.05 (0.81 to 1.35)1181.15 (0.88 to 1.49)1441.35 (1.05 to 1.73)0.08
Death from cardiac causes561.00 (reference)521.01 (0.69 to 1.48)601.19 (0.82 to 1.72)781.58 (1.12 to 2.25)0.03
Sudden cardiac death311.00 (reference)301.06 (0.64 to 1.76)361.29 (0.79 to 2.11)491.84 (1.16 to 2.91)0.03
Nonfatal myocardial infarction471.00 (reference)350.81 (0.52 to 1.26)361.00 (0.64 to 1.56)330.91 (0.57 to 1.44)0.08
Fatal stroke71.00 (reference)91.35 (0.50 to 3.66)40.63 (0.18 to 2.18)141.97 (0.76 to 5.09)0.19
Nonfatal stroke101.00 (reference)212.24 (1.05 to 4.79)181.89 (0.86 to 4.13)191.91 (0.88 to 4.17)0.21
All cardiac events combined1431.00 (reference)1170.87 (0.68 to 1.11)1321.08 (0.85 to 1.38)1421.17 (0.92 to 1.48)0.11
All cerebrovascular events combined321.00 (reference)401.29 (0.81 to 2.07)341.18 (0.72 to 1.93)551.83 (1.17 to 2.85)0.04
Stroke171.00 (reference)301.79 (0.98 to 3.26)221.47 (0.77 to 2.80)332.02 (1.11 to 3.68)0.12
Death (all causes)1171.00 (reference)1281.14 (0.88 to 1.47)1481.33 (1.04 to 1.71)1711.47 (1.15 to 1.88)0.01
Death (noncardiovascular disease causes)541.00 (reference)671.21 (0.84 to 1.75)841.63 (1.15 to 2.31)791.40 (0.98 to 2.00)0.05
  • P value of multivariate Cox regression model comparing the hazard ratios across the four groups. Risk factors included in the multivariate regression model were age, sex, body mass index, total cholesterol, albumin, hemoglobin, glycated hemoglobin, phosphate, leukocytes, serum creatinine, diastolic BP, duration of dialysis, duration of diabetes, use of statins, use of calcium antagonists, use of angiotension-coverting enzyme inhibitors, history of coronary artery disease, ischemia, arrhythmia, congestive heart failure, peripheral vascular disease, and atorvastatin treatment. SP-B, surfactant protein B; 95% CI, 95% confidence interval.