Table 2.

Univariate Cox proportional hazard model of first heart failure event during follow-up in patients on hemodialysis

VariableUnit of IncreaseHazard Ratio (95% Confidence Interval)P value
Age1 yr1.02 (0.99 to 1.04)0.06
SexWomen versus men0.82 (0.50 to 1.34)0.43
Body mass index1 kg/m21.01 (0.94 to 1.09)0.77
Systolic BP1 mmHg1.01 (0.99 to 1.03)0.06
Diastolic BP1 mmHg1.01 (0.98 to 1.03)0.68
Dialysis duration1 mo0.99 (0.99 to 1.01)0.58
Average interdialytic weight gain1%1.02 (0.88 to 1.04)0.68
Ultrafiltration volume1 ml1.01 (0.69 to 1.23)0.46
Urinary volume1 ml/kg per 24 h0.96 (0.92 to 1.01)0.11
Residual renal function1 ml/min per 1.73 m20.70 (0.46 to 1.08)0.11
Single-pool Kt/V10.59 (0.25 to 1.37)0.22
Normalized protein nitrogen appearance rate1 g/kg per d0.98 (0.58 to 1.64)0.93
Smoking historyPresent versus absent1.26 (0.78 to 2.04)0.35
History of primary hypertensionPresent versus absent2.25 (1.39 to 3.64)0.001
History of coronary heart diseasePresent versus absent5.14 (2.58 to 10.26)<0.001
History of diabetesPresent versus absent1.74 (0.93 to 3.24)0.08
History of taking calcium channel blockerYes versus no1.26 (0.76 to 2.09)0.38
History of taking angiotensin conversion enzyme inhibitorYes versus no0.98 (0.53 to 1.83)0.95
History of taking angiotensin receptor blockerYes versus no1.41 (0.86 to 2.32)0.17
History of taking β-blockerYes versus no0.84 (0.43 to 1.64)0.61
History of taking α-blockerYes versus no1.47 (0.84 to 2.57)0.18
History of taking aspirinYes versus no0.88 (0.48 to 1.61)0.67
History of taking statinYes versus no1.32 (0.53 to 3.28)0.55
Albumin1 g/L0.99 (0.93 to 1.06)0.84
Prealbumin1 g/L0.06 (0.01 to 1.27)0.07
BUN1 mmol/L1.04 (0.99 to 1.08)0.11
Serum creatinine1 μmol/L1.00 (0.99 to 1.01)0.48
Uric acid1 μmol/L1.00 (0.99 to 1.01)0.53
P1 mmol/L1.01 (0.69 to 1.46)0.99
Ca×P1 mmol2/L20.99 (0.99 to 1.01)0.79
Intact parathyroid hormone1 pg/ml1.00 (1.00 to 1.01)0.28
25-Hydroxy vitamin D1 mmol/L0.97 (0.96 to 0.99)<0.01
LDL-cholesterol1 mmol/L0.68 (0.50 to 0.92)0.01
HDL-cholesterol1 mmol/L0.88 (0.41 to 1.92)0.75
Apoprotein-A1 g/L0.83 (0.29 to 2.37)0.73
Apoprotein-B1 g/L0.28 (0.09 to 0.91)0.03
Homocysteine1 μmol/L1.00 (0.99 to 1.01)0.64
High-sensitivity C-reactive protein1 mg/L1.00 (0.99 to 1.02)0.45
β2-Microglobulin1 mg/L0.99 (0.98 to 1.02)0.93
Indoxyl sulfate (continuous variable)1 μg/ml1.02 (1.01 to 1.03)0.001
Indoxyl sulfate (dichotomous variable)High versus low3.49 (1.97 to 6.20)<0.001
Left ventricular mass index (g/m2.7)1 g/m2.71.03 (1.02 to 1.04)<0.001
Left ventricular ejection fraction (%)1%0.95 (0.92 to 0.98)0.001