Univariate Cox proportional hazard model of first heart failure event during follow-up in patients on hemodialysis
Variable | Unit of Increase | Hazard Ratio (95% Confidence Interval) | P value |
---|---|---|---|
Age | 1 yr | 1.02 (0.99 to 1.04) | 0.06 |
Sex | Women versus men | 0.82 (0.50 to 1.34) | 0.43 |
Body mass index | 1 kg/m2 | 1.01 (0.94 to 1.09) | 0.77 |
Systolic BP | 1 mmHg | 1.01 (0.99 to 1.03) | 0.06 |
Diastolic BP | 1 mmHg | 1.01 (0.98 to 1.03) | 0.68 |
Dialysis duration | 1 mo | 0.99 (0.99 to 1.01) | 0.58 |
Average interdialytic weight gain | 1% | 1.02 (0.88 to 1.04) | 0.68 |
Ultrafiltration volume | 1 ml | 1.01 (0.69 to 1.23) | 0.46 |
Urinary volume | 1 ml/kg per 24 h | 0.96 (0.92 to 1.01) | 0.11 |
Residual renal function | 1 ml/min per 1.73 m2 | 0.70 (0.46 to 1.08) | 0.11 |
Single-pool Kt/V | 1 | 0.59 (0.25 to 1.37) | 0.22 |
Normalized protein nitrogen appearance rate | 1 g/kg per d | 0.98 (0.58 to 1.64) | 0.93 |
Smoking history | Present versus absent | 1.26 (0.78 to 2.04) | 0.35 |
History of primary hypertension | Present versus absent | 2.25 (1.39 to 3.64) | 0.001 |
History of coronary heart disease | Present versus absent | 5.14 (2.58 to 10.26) | <0.001 |
History of diabetes | Present versus absent | 1.74 (0.93 to 3.24) | 0.08 |
History of taking calcium channel blocker | Yes versus no | 1.26 (0.76 to 2.09) | 0.38 |
History of taking angiotensin conversion enzyme inhibitor | Yes versus no | 0.98 (0.53 to 1.83) | 0.95 |
History of taking angiotensin receptor blocker | Yes versus no | 1.41 (0.86 to 2.32) | 0.17 |
History of taking β-blocker | Yes versus no | 0.84 (0.43 to 1.64) | 0.61 |
History of taking α-blocker | Yes versus no | 1.47 (0.84 to 2.57) | 0.18 |
History of taking aspirin | Yes versus no | 0.88 (0.48 to 1.61) | 0.67 |
History of taking statin | Yes versus no | 1.32 (0.53 to 3.28) | 0.55 |
Albumin | 1 g/L | 0.99 (0.93 to 1.06) | 0.84 |
Prealbumin | 1 g/L | 0.06 (0.01 to 1.27) | 0.07 |
BUN | 1 mmol/L | 1.04 (0.99 to 1.08) | 0.11 |
Serum creatinine | 1 μmol/L | 1.00 (0.99 to 1.01) | 0.48 |
Uric acid | 1 μmol/L | 1.00 (0.99 to 1.01) | 0.53 |
P | 1 mmol/L | 1.01 (0.69 to 1.46) | 0.99 |
Ca×P | 1 mmol2/L2 | 0.99 (0.99 to 1.01) | 0.79 |
Intact parathyroid hormone | 1 pg/ml | 1.00 (1.00 to 1.01) | 0.28 |
25-Hydroxy vitamin D | 1 mmol/L | 0.97 (0.96 to 0.99) | <0.01 |
LDL-cholesterol | 1 mmol/L | 0.68 (0.50 to 0.92) | 0.01 |
HDL-cholesterol | 1 mmol/L | 0.88 (0.41 to 1.92) | 0.75 |
Apoprotein-A | 1 g/L | 0.83 (0.29 to 2.37) | 0.73 |
Apoprotein-B | 1 g/L | 0.28 (0.09 to 0.91) | 0.03 |
Homocysteine | 1 μmol/L | 1.00 (0.99 to 1.01) | 0.64 |
High-sensitivity C-reactive protein | 1 mg/L | 1.00 (0.99 to 1.02) | 0.45 |
β2-Microglobulin | 1 mg/L | 0.99 (0.98 to 1.02) | 0.93 |
Indoxyl sulfate (continuous variable) | 1 μg/ml | 1.02 (1.01 to 1.03) | 0.001 |
Indoxyl sulfate (dichotomous variable) | High versus low | 3.49 (1.97 to 6.20) | <0.001 |
Left ventricular mass index (g/m2.7) | 1 g/m2.7 | 1.03 (1.02 to 1.04) | <0.001 |
Left ventricular ejection fraction (%) | 1% | 0.95 (0.92 to 0.98) | 0.001 |