Table 3.

Symptoms and QOL at the initial clinic visit and change in symptoms and QOL over time in the RSC-NFD and predialysis groups

PredialysisRSC-NFDP Value
 No. of symptoms at first visit (MSAS), mean (SD)9.1 (5.3)12.2 (5.6)<0.001
 Score >20 at first visit (MSAS)44 (33%)37 (57%)0.001
 Physical composite (SF-36)13763
  Score at first visit; mean (SD)38 (11)29 (8)<0.001
 Mental composite (SF-36)
  Score at first visit; mean (SD)50 (10)46 (12)0.06
QOL status4919
 Change of physical composite score over 12 mo0.12
  Stable2 (4%)3 (16%)
  Improved20 (41%)4 (21%)
  Worse27 (55%)12 (63%)
 Change of mental composite score over 12 mo0.78
  Stable1 (2%)1 (5%)
  Improved26 (53.1%)10 (53%)
  Worse22 (44.9%)8 (42%)
MSAS symptom status
 Change of MSAS symptoms score from initial visit to 6 mo8445
  Stable6 (7%)3 (8%)0.88
  Improved32 (38%)16 (42%)
  Worse46 (55%)19 (50%)
 Change of MSAS symptoms score from initial visit to 12 mo48210.12
  Stable5 (10%)1 (5%)
  Improved15 (31%)12 (57%)
  Worse28 (58%)8 (38%)
POS-S symptom status78
 Change of POS-S (renal) score over 6 mo
  Stable3 (4%)
  Improved48 (62%)
  Worse27 (35%)
 Change of POS-S (renal) score over 12 mo69
  Stable3 (4%)
  Improved49 (71%)
  Worse17 (25%)
  • Data are n unless otherwise stated. The overall initial survey response rate was 51% for both the MSAS and SF-36 forms. Missing data from follow-up visits were mostly due to deaths or else failure to return the voluntary MSAS or SF-36 forms. Data for symptom assessment using the POS-S form in the RSC-NFD group were more complete as this was conducted at the time of their clinic visit. QOL, quality of life; MSAS, Memorial Symptom Assessment Scale; SF-36, Short Form-36.