Table 4.

Incidence of infections except for cytomegalovirus at 12 months

VariablesValganciclovir (n=60)Valacyclovir (n=59)P Value
Herpes simplex virus9 (15)8 (14)0.97
Varicella zoster virus2 (3)0 (0)0.48
Epstein–Barr virus disease1 (2)1 (2)0.48
Polyoma BK virus
 Viremia21 (36)10 (18)0.04a
 Viremia≥10,000 copies/ml5 (8)3 (5)0.73
 Nephropathy6 (10)2 (4)0.42
 Peak viral load (copies/ml), mean±SD7400±15,0008950±15,8000.50
Other viral infection15 (25)18 (31)0.64
Fungal infection6 (10)10 (17)0.40
Pneumocystis0 (0)0 (0)
Any bacterial infection30 (50)39 (66)0.11
Urinary tract infection11 (18)19 (32)0.13
Pneumonia5 (8)4 (7)0.98
Sepsis11 (18)10 (17)0.97
  • Data are n (%) unless otherwise indicated.

  • a Hazard ratio, 0.43; 95% confidence interval, 0.19 to 0.96 after adjustment for age, previous transplantation, peak panel reactive antibodies, HLA mismatches, calcineurin inhibitor, induction therapy, donor age, donor type, expanded criteria donor, and delayed graft function.