Table 3.

Association of baseline N-terminal pro–B-type natriuretic peptide and troponin T with absolute decline of kidney function (n=3062)

Annual Change (95% Confidence Interval) in eGFR (n=3062)
Mean (SD) Unadjusted Rate (ml/min per year)Model 1aModel 2b
NT-proBNP quartiles (pg/ml)
 ≤58−1.93 (2.40)0 (reference)0 (reference)
 59–115−2.02 (2.30)−0.14 (−0.34 to 0.06)−0.17 (−0.37 to 0.03)
 116–237−2.07 (2.37)−0.28 (−0.49 to −0.07)c−0.30 (−0.51 to −0.09)c
 >237−2.43 (2.85)−0.49 (−0.76 to −0.22)c−0.48 (−0.75 to −0.20)c
Troponin T categories (pg/ml)
 ≤2.99−1.93 (2.19)0 (reference)0 (reference)
 3.00–5.57−2.10 (2.34)−0.14 (−0.36 to 0.07)−0.11 (−0.32 to 0.10)
 5.58 10.58−2.09 (2.23)−0.12 (−0.33 to 0.08)−0.01 (−0.20 to 0.20)
 >10.58−2.41 (3.08)−0.48 (−0.75 to −0.20)c−0.33 (−0.59 to −0.06)c
  • NT-proBNP, N-terminal pro–B-type natriuretic peptide.

  • a Adjusted for demographics and baseline eGFR.

  • b Additionally adjusted for body mass index, diastolic BP, systolic BP, hypertension medications, diabetes mellitus, and prevalent cardiovascular disease.

  • c P<0.05.