Associations of urine α1-microglobulin with kidney function decline in HIV-uninfected women
| 3% Annual eGFRCys Decline | 5% Annual eGFRCys Decline | |||||
|---|---|---|---|---|---|---|
| C1 | C2 | C3 | C1 | C2 | C3 | |
| Range of α1m/cr (mg/g) | — | 0.1–0.8 | >0.8 | — | 0.1–0.8 | >0.8 |
| No. at risk | 173 | 57 | 57 | 173 | 57 | 57 |
| No. events | 33 | 18 | 30 | 13 | 7 | 14 |
| Risk Ratio (95% CI) | Risk Ratio (95% CI) | Risk Ratio (95% CI) | Risk Ratio (95% CI) | |||
| Demographic adjusteda | Reference | 1.65 (1.06 to 2.56) | 2.23 (1.52 to 3.29) | Reference | 1.46 (0.64 to 3.32) | 2.30 (1.19 to 4.46) |
| Multivariate adjustedb | — | 1.77 (1.10 to 2.84) | 2.16 (1.37 to 3.38) | — | 1.55 (0.68 to 3.52) | 2.28 (1.16 to 4.51) |
| Adjusted+ACRc | — | 1.77 (1.10 to 2.83) | 2.21 (1.41 to 3.45) | — | 1.68 (0.73 to 3.89) | 2.19 (1.12 to 4.29) |
| Adjusted+ACR, IL-18, KIM-1, NGALd | — | 1.61 (1.02 to 2.55) | 2.13 (1.39 to 3.28) | — | 1.72 (0.76 to 3.93) | 2.28 (1.19 to 4.38) |
Standardized to urine creatinine and stratified by categories. Category 1 comprises all participants with undetectable urine α1-microglobulin. All analyses use category 1 as the reference category. eGFRCys, cystatin C-based eGFR; C1, category 1; C2, category 2; C3, category 3; α1m/cr, α1–microglobulin-to-creatinine ratio; ACR, albumin-to-creatinine ratio; KIM-1, kidney injury molecule-1.
↵a Adjusted for age and race.
↵b Adjusted for age, race, baseline eGFRCys, hypertension, diabetes mellitus, hepatitis C virus infection, smoking, systolic blood pressure, and serum albumin.
↵c Adjusted for all covariates listed above with the addition of ACR.
↵d Adjusted for all covariates listed above with the addition of ACR, IL-18, KIM-1, NGAL, and liver fatty acid binding protein.