Table 1.

Participant characteristics by bicarbonate level

CharacteristicBicarbonate Category (mEq/L)P for Trend
<23 (n=149)23–25.9 (n=814)≥26 (n=581)
Age, yr75.5±2.775.4±2.875.5±2.90.80
Race, black (%)51 (34.2)263 (32.3)221 (38.0)0.08
Sex, women (%)60 (40.3)366 (45.0)299 (51.5)0.003
CKD (%)38 (25.5)111 (13.6)64 (11.0)<0.001
Diabetes (%)37 (25.8)140 (17.2)93 (16.0)0.04
BMI, kg/m226.3±4.426.8±4.126.6±4.70.44
Smoking (%)<0.001a
 None50 (33.6)364 (44.6)294 (50.6)
 Former72 (48.3)392 (48.2)261 (44.9)
 Current27 (18.1)58 (7.1)26 (4.5)
Diuretic use (%)20 (13.4)135 (16.6)218 (37.5)<0.001
Usual gait speed, m/s1.17±0.201.22±0.201.19±0.190.40
pH (range)7.40±0.04 (7.31–7.57)7.41±0.02 (7.31–7.48)7.41±0.03 (7.31–7.59)<0.001
Pco2, mmHg35.2±3.239.2±2.543.3±3.3<0.001
NEAP, mEq/d41.2±13.139.2±10.736.4±10.90.001
  • BMI, body mass index; NEAP, net endogenous acid production.

  • a P value by chi-squared test and not by trend.