Table 4.

Sensitivity analysis of characteristics associated with glomerular volume, mean profile tubular area, total glomerular density, and globally sclerotic glomerular density

CharacteristicOriginal 
Analysis (n=1236)At least 4 mm2 
of Cortex (n=1072)0% Interstitial 
Fibrosis (n=956)aAdjusted Depth and 
Amount of Biopsy (n=1236)
Percent DifferenceP ValuePercent DifferenceP ValuePercent DifferenceP ValuePercent DifferenceP Value
Mean nonsclerotic glomerular volume
 Age, per 10 yr0.06 0.95−0.10.960.3 0.760.3 0.75
 Men7.3 0.0044.80.068.0 0.017.1 0.004
 24-h Urine albumin excretion, per doubling1.8 0.011.80.011.5 0.051.3 0.04
 Measured GFR (ml/min per 1.73 m)2b2.0 0.081.10.351.7 0.182.2 0.05
 Hypertension3.6 0.292.10.5510 0.023.7 0.27
 Family history of ESRDb7.3 <0.0017.7<0.0016.6 0.017.0 <0.001
 Uric acidb3.6 0.014.40.0013.7 0.013.6 0.01
 BMIb8.2 <0.0018.3<0.0018.0<0.0018.4 <0.001
 Area of cortex3.0 <0.001
 Corticomedullary junction0.3 0.91
 Capsule−13 0.01
Mean profile tubular area
 Age, per 10 yr2.4 0.012.40.022.6 0.012.7 0.003
 Men4.9 0.033.70.116.8 0.014.5 0.04
 24-h Urine albumin excretion, doubling2.4 <0.0012.2<0.0012.0 0.0031.8 0.001
 Measured GFR (ml/min per 1.73 m)2b3.1 0.0023.00.013.2 0.0043.3 <0.001
 Hypertension3.4 0.273.40.314.1 0.283.7 0.21
 Family history of ESRDb4.3 0.025.20.014.3 0.044.0 0.03
 Uric acidb0.15 0.900.60.63−0.8 0.550.1 0.93
 BMIb4.2 <0.0014.3<0.0013.9<0.0014.5 <0.001
 Area of cortex3.3<0.001
 Corticomedullary junction3.4 0.18
 Capsule−5.3 0.19
Total glomerular density
 Age, per 10 yr−4.2 <0.001−3.60.01−5.6<0.001−4.2<0.001
 Men−3.2 0.29−0.90.77−3.80.27−3.50.24
 24-h Urine albumin excretion, doubling−3.3 <0.001−3.5<0.001−2.20.02−2.9<0.001
 Measured GFR (ml/min per 1.73 m)2b−0.1 0.50−1.10.44−1.20.43−1.00.46
 Hypertension4.6 0.292.50.57−3.60.494.40.31
 Family history of ESRDb−10 <0.001−10<0.001−11<0.001-9.0<0.001
 Uric acidb−4.7 0.003−5.8<0.001−4.90.01−4.70.003
 BMIb−8.0 <0.001-7.2<0.001−7.7<0.001−8.3<0.001
 Area of cortex−1.9<0.001
 Corticomedullary junction−7.70.03
 Capsule26<0.001
GSG density
 Age, per 10 yr13.5 <0.00114.4<0.0018.4<0.00113.6<0.001
 Men−3.8 0.31−5.70.13−2.90.44−4.10.27
 24-h Urine albumin excretion, doubling−2.1 0.03−2.10.04−0.80.44−20.05
 Measured GFR, ml/min per 1.73 m2b1.3 0.030.60.74−1.10.521.30.45
 Hypertension28.8 <0.00126<0.00116.40.0128.5<0.001
 Family history of ESRDb3.1 0.333.50.295.20.1030.35
 Uric acidb−0.5 0.800.10.99−1.50.44−0.50.8
 BMIb−2.8 0.09−2.40.170.40.82−30.07
 Area of cortex−0.40.57
 Corticomedullary junction−7.50.08
 Capsule10.90.17
  • All findings are multivariable adjusted.

  • a Only 2.9% of donors had ≥5% interstitial fibrosis, but we used the strictest criteria for this sensitivity analysis.

  • b Per SD.