Table 3.

Association of kidney function and CKD risk factors with glomerular density

CharacteristicGlomerular DensityNSG DensityGSG Density
UnadjustedMultivariable AdjustedUnadjustedMultivariable AdjustedUnadjustedMultivariable Adjusted
Percent DifferenceP 
ValuePercent DifferenceP 
ValuePercent DifferenceP 
ValuePercent DifferenceP 
ValuePercent DifferenceP 
ValuePercent DifferenceP 
Value
Age, per 10 yr−1.9 0.06−4.2<0.001−4.4<0.001−6.6<0.00116 <0.00114 <0.001
Men−10 <0.001−3.2 0.29−10<0.001−3.2 0.31−6.8 0.02−3.8 0.31
24-h Urine protein excretiona−0.8 0.54−1.2 0.371.97 0.22
24-h Urine albumin excretion, per doubling−4.1 <0.001−3.3 <0.001−3.8<0.001−3.1<0.001−2.9 0.003−2.1 0.03
Measured GFRa (ml/min)−4.6 <0.001−3.8 0.004−7.6 <0.001
Measured GFR (ml/min per 1.73 m)2a1.1 0.38−0.1 0.501.9 0.16−1.7 0.25−5.9 <0.0011.3 0.46
18-h Overall SBPa−5.1 <0.001−5.9<0.0013.1 0.04
18-h Overall DBPa−4.0 <0.001−4.6<0.0012.6 0.09
Hypertension−5.1 0.184.6 0.29−11.6 0.002−0.7 0.8742 <0.00129 <0.001
Family history of ESRD−9.6 <0.001−10 <0.001−9.2<0.001−11<0.001−5.5 0.073.1 0.33
Triglyceridesa−4.5 <0.001−4.5<0.001−1.2 0.43
HDL cholesterola6.0 <0.0015<0.001−6.7 <0.001
LDL cholesterola−1.3 0.291.4 0.300.7 0.65
Glucosea−4.2 <0.001−4.7<0.0012.4 0.13
Uric acida−8.1 <0.001−4.7 0.003−8.1<0.001−4.9 0.0032.3 0.13−0.5 0.80
BMIa−10 <0.001−8.0 <0.001−9.8<0.001−7.4<0.001−2.8 0.06−2.8 0.09
Metabolic syndrome−15 <0.001−15<0.0012.1 0.66
  • SBP, systolic BP; DBP, diastolic BP.

  • a Per SD.