Table 3.

Summary statistics for urine biomarkers by progression and mortality

MarkerNo Progression (n=95)Progression without Death (n=44)P Value (versus No Progression)Progression with Death (n=39)P Value (versus No Progression)Overall P Valuea
Tubular injury marker
 NGAL (ng/ml)76 (17–180)100 (49–544)0.02366 (112–910)<0.001<0.001
 IL-18 (pg/ml)15 (15–62)21 (15–67)0.3890 (15–325)<0.001<0.001
 KIM-1 (ng/ml)5 (1.8–11.7)5.8 (2.6–9.5)0.968.3 (4–17.1)0.0040.01
 L-FABP (ng/ml)8 (3–19)12 (6–29)0.0638 (13–73)<0.001<0.001
Tubular function marker
 FENa (%)0.32 (0.1–0.89)0.15 (0.04–0.59)0.020.31 (0.1–0.91)0.970.04
Glomerular injury marker
 Albumin (mg/dl)21 (5–73)29 (9–164)0.2384 (45–233)<0.001<0.001
  • Data are presented as the median (interquartile range). NGAL, neutrophil gelatinase–associated lipocalin; KIM-1, kidney injury molecule-1; L-FABP, liver-type fatty acid–binding protein; FENa, fractional excretion of sodium.

  • a P value from overall ANOVA model.