Table 3.

Multivariable adjusted hazards ratios (95% confidence intervals) for all-cause mortality associated with number of nondisease-specific problems among the REGARDS Study population ≥75 years old by eGFR

No. of Nondisease-Specific ProblemseGFR, ml/min per 1.73 m2
≥6045–59<45
n2616606335
01 (reference)1 (reference)1 (reference)
11.34 (1.08 to 1.67)1.17 (0.78 to 1.76)1.52 (0.93 to 2.49)
21.91 (1.47 to 2.47)1.95 (1.24 to 3.07)1.90 (1.12 to 3.22)
3–62.28 (1.67 to 3.10)2.44 (1.39 to 4.27)1.64 (0.88 to 3.07)
P trend<0.001<0.0010.04
  • Multivariable adjustment includes age, race, sex, education, income, region of residence, current cigarette smoking, atrial fibrillation, coronary heart disease, stroke, diabetes, systolic BP, diastolic BP, waist circumference, HDL cholesterol, total cholesterol, and C-reactive protein (log transformed).