Table 1.

Conventional indications for RRT

IndicationReported Any Time before RRT (134)First Indication
All (134)Classic-Urgent (90)Classic-Delayed (44)
Time from admission to indication (h)0.5 [0.0–3.3]0.4 [0.0–1.6]1.8 [0.3–16.7]
Time from indication to RRT (h)4.8 [1.9–17.7]2.5 [0.9–4.9]23.8 [17.7–43.2]
Hyperkalemia K≥6 mEq/L41 (30.6)25 (18.7)20 (22.2)5 (11.4)
Severe acidosis (pH≤7.15)70 (52.2)48 (35.8)26 (28.9)22 (50.0)
Plasma urea>36 mmol/La26 (19.4)b15 (11.2)14 (15.6)1 (2.3)
Oliguria or anuria (urine output<0.3 ml/kg per hour for ≥24 h or anuria for ≥12 h)40 (29.9)39 (29.1)28 (31.1)11 (25.0)
Fluid overload with pulmonary edemac12 (9.0)7 (5.2)2 (2.2)5 (11.4)
  • Data are expressed as number (percentage) or median [interquartile range].

  • a Equals BUN of 100.8 mg/dl.

  • b Thirteen of 26 (50.0%) patients also had at least one other conventional indication.

  • c All components listed had to be met: fluid accumulation>10% of weight, respiratory Sequential Organ Failure Assessment score≥3, and oliguria (urine output criteria for AKI stage 2 or 3 present). Stage 2, urine output<0.5 ml/kg per hour for ≥12 hours; stage 3, urine output<0.3 ml/kg per hour for ≥24 hours or anuria for ≥12 hours.