Table 1.

Characteristics of all participants

CharacteristicsDonors Predonation (n=134)Donors Postdonation (n=134)ADPKD (n=122)P Value Predonation/PostdonationP Value Predonation/ ADPKDP Value Postdonation/ ADPKD
Age (yr)52±1052±1040±12<0.001<0.001<0.001
Men (%)4949560.300.30
Use of antihypertensives (%)151585>0.99<0.001<0.001
Use of diuretics (%)54200.32<0.001<0.001
Body surface area (m2)1.96±0.201.95±0.202.02±0.23<0.010.02<0.01
Mean arterial pressure (mmHg)92±1090±995±90.002<0.01<0.001
Hemoglobin (mg/dl)14.3±1.113.5±1.113.4±1.5<0.001<0.0010.51
Plasma osmolality (mosM/kg)291±4290±4289±40.11<0.0010.002
Plasma sodium (mEq/L)142.3±1.9141.6±1.8140.4±1.8<0.001<0.001<0.001
Plasma urea (mg/dl)16.0±3.419.3±4.224.1±12.6<0.001<0.001<0.001
24-h urine volume (L)2600 (2200–3050)2208 (1713–2700)2200 (1785–2673)<0.001<0.0010.51
24-h urine osmolality (mosM/kg)372 (320–459)412 (343–530)396 (314–474)<0.0010.540.06
24-h urine sodium (mmol/24 h)197 (156–249)169 (132–216)161 (128–215)<0.001<0.0010.34
24-h urine urea (mg/24 h)1140 (983–1350)1297 (1028–1669)1089 (905–1311)<0.001<0.16<0.001
GFR (ml/min per 1.73 m2)105±1766±1074±32<0.001<0.0010.01
U/P urea29.2 (23.3–35.1)27.1 (20.9–34.5)23.3 (15.2–31.1)0.10<0.0010.001
Total kidney volume (ml)1535 (931–2356)
Plasma copeptin (pmol/L)3.8 (2.8–6.3)4.4 (3.1–6.1)6.8 (3.4–15.7)0.17<0.001<0.001
  • Data are given as mean ± SD for parametric data or median (interquartile range) for nonparametric data. Significance between predonation and postdonation was tested using a paired t test or a Wilcoxon signed rank test when appropriate. Significance of difference between predonation and postdonation was tested using a paired t test or a Wilcoxon signed rank test when appropriate. Significance of differences between predonation/postdonation and ADPKD was tested using a t test, a chi-squared test, or a Mann–Whitney U test when appropriate. U/P urea, urine-to-plasma concentration ratio of urea; ADPKD, autosomal dominant polycystic kidney disease.