Table 1.

Patient characteristics

CharacteristicPE (n=11)PC (n=25)HC (n=14)NPC (n=13)
Age, yr32.5 (29.5–35.8)31.0 (28.3–36.6)41.8 (34.4–43.5)a33.5 (24.6–40.0)
Gestational age, wk35.7 (34.1–39.0)33.4 (16.7–40.0)NANA
Parity, mean (SD)0.6 (1.0)0.8 (1.0)NANA
Proteinuria, g/24 h0.36 (0.3–6.1)NANANA
BP, mmHg
 Systolic160.0 (141.3–191.3)b125.0 (113.5–137.5)NANA
 Diastolic106.0 (87.5–120.0)c90.0 (70.0–90.0)NANA
Antihypertensive therapy, n (%)4 (36)NA4 (100)dNA
Comorbidities, n (%)
 Sickle cell anemia0 (0)1 (4)0 (0)0 (0)
 WPW syndrome0 (0)1 (4)0 (0)0 (0)
 Asthma0 (0)2 (8)0 (0)0 (0)
 Hyperhomocysteinemia0 (0)2 (8)0 (0)0 (0)
 Hypertension1 (9)0 (0)0 (0)0 (0)
 Epilepsy1 (9)0 (0)0 (0)0 (0)
 Breast cancer0 (0)0 (0)1 (7)0 (0)
 Renal insufficiency0 (0)0 (0)2 (14)0 (0)
 Depression0 (0)0 (0)2 (14)0 (0)
 Obesity0 (0)0 (0)3 (21)1 (8)
Cause of death, n (%)
 Preeclampsia related11 (100)0 (0)0 (0)0 (0)
 Ectopic pregnancy0 (0)1 (4)0 (0)0 (0)
 Thromboembolism0 (0)6 (24)2 (14)0 (0)
 Amniotic fluid embolism0 (0)2 (8)0 (0)0 (0)
 Arrhythmias0 (0)1 (4)0 (0)0 (0)
 Cardiac arrest0 (0)1 (4)2 (14)0 (0)
 Unknown0 (0)2 (8)1 (7)0 (0)
 Malignancy0 (0)1 (4)1 (7)0 (0)
 Aorta dissection0 (0)3 (12)4 (29)0 (0)
 Infection0 (0)5 (20)1 (7)0 (0)
 Cardiomyopathy0 (0)2 (8)0 (0)0 (0)
 Pheochromocytoma0 (0)1 (4)0 (0)0 (0)
 Cerebral bleeding0 (0)0 (0)3 (21)0 (0)
 Suicide0 (0)0 (0)0 (0)5 (38)
 High energy trauma0 (0)0 (0)0 (0)7 (54)
 Drowning0 (0)0 (0)0 (0)1 (8)
Death-autopsy interval, h18.0 (6.0–32.3)24.0 (20.5–24.0)24.0 (12.0–48.0)24.0 (24.0–60.0)
  • Data are given as the median (IQR) unless otherwise specified. PE, preeclampsia; PC, normotensive pregnant control; HC, hypertensive nonpregnant control; NPC, normotensive nonpregnant control; NA, not applicable; WPW, Wolff–Parkinson–White.

  • a P=0.03.

  • b P=0.001.

  • c P=0.01.

  • d Data on hypertensive therapy of the hypertensive controls were available from four patients.