Table 2.

rs35238405 (T233A) single single-nucleotide polymorphism association testing (dominant model) with adjustment for admixture and apolipoprotein L1 gene G1/G2 allele status

StudyN Patient/ControlMAF Patient/ControlP ValueOR95% CI
T2D-GENES (exome sequence)528/5140.014/0.00560.0802.360.90 to 6.16
T2D-ESRD Replication1255/6730.010/0.00220.0184.301.29 to 14.34
Non-T2D ESRD1487/6730.012/0.00220.0164.481.33 to 15.11
T2D-only (versus controls)480/11870.0073/0.00380.162.040.75 to 5.53
All-cause ESRD3270/11870.012/0.00380.00382.821.40 to 5.68
  • Sample sizes reflect those patients with complete clinical and genotypic data used in each analysis. MAF, minor allele frequency; OR, odds ratio; 95% CI, 95% confidence interval; T2D, type 2 diabetes mellitus; ESRD, end stage renal disease.