Table 4.

Nephrin gene variants nominally associated with end stage renal disease in locus-wide analysis using single single-nucleotide polymorphism association testing after adjustment for admixture and apolipoprotein L1 gene G1/G2 allele status

StudySNPN Patient/ControlMAF Patient/ControlP ValueOR95% CI
T2D-ESRD Replicationrs115489112 (Y1174H)a1222/6420.0025/0.00780.0220.290.10 to 0.84
All-cause ESRDrs115489112 (Y1174H)a2673/6420.0039/0.00780.0360.440.20 to 0.95
All-cause ESRDrs146400394 (H800R)b2757/6420.00020/0.00220.00840.040 to 0.44
  • Sample sizes reflect those patients with complete clinical and genotypic data used in each analysis. SNP, single-nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio; 95% CI, 95% confidence interval; T2D, type 2 diabetes mellitus; ESRD, end stage renal disease.

  • a Additive model.

  • b Dominant model.