Table 3.

The association of retinopathy with eGFR slope (ml/min per 1.73 m2 per year)

LevelAt Risk (n)Model 1 (Unadjusted)Model 2 (Partially Adjusted)Model 3 (Partially Adjusted)Model 4 (Fully Adjusted)
Slope Difference (95% CI)P ValueSlope Difference (95% CI)P ValueSlope Difference (95% CI)P ValueSlope Difference (95% CI)P Value
Any retinopathy
 No retinopathy11340<0.00100.9500.2600.88
 Retinopathy442−0.93 (−1.27 to −0.59)−0.04 (−0.38 to +0.31)−0.27 (−0.64 to +0.10)−0.01 (−0.36 to +0.33)
 Ungradable89−0.89 (−1.59 to −0.20)−0.09 (−0.74 to +0.56)−0.38 (−1.07 to +0.32)−0.17 (−0.83 to +0.49)
Retinal level
 No retinopathy11340<0.00100.7700.0800.62
 Mild NPR116−0.50 (−1.07 to +0.08)−0.07 (−0.61 to +0.46)−0.05 (−0.63 to +0.52)−0.05 (−0.59 to +0.50)
 NPR187−0.83 (−1.31 to −0.36)0.15 (−0.32 to +0.62)−0.07 (−0.58 to +0.44)0.21 (−0.27 to +0.69)
 PR139−1.47 (−2.04 to −0.90)−0.28 (−0.84 to +0.29)−0.84 (−1.43 to -0.24)−0.31 (−0.88 to +0.26)
 Ungradable89−0.89 (−1.58 to −0.20)−0.09 (−0.74 to +0.56)−0.39 (−1.08 to +0.31)−0.17 (−0.83 to +0.49)
Arteriole diameter, quartile (µm)
 First (≤140)35000.5400.6100.6400.58
 Second (>140, ≤149)359−0.01 (−0.45 to +0.43)−0.03 (−0.43 to +0.37)−0.09 (−0.53 to +0.34)−0.03 (−0.44 to +0.38)
 Third (>149, ≤159)3430.25 (−0.19 to +0.69)0.11 (−0.30 to +0.52)0.12 (−0.32 to +0.57)0.12 (−0.30 to +0.53)
 Fourth (>159)353−0.05 (−0.49 to +0.39)−0.16 (−0.58 to +0.25)−0.15 (−0.60 to +0.31)−0.17 (−0.59 to +0.25)
Venular diameter, quartile (µm)
 First (≤204)35900.0600.5000.3100.52
 Second (>204, ≤219)3640.27 (−0.16 to +0.70)0.28 (−0.11 to +0.67)0.17 (−0.26 to +0.59)0.25 (−0.14 to +0.65)
 Third (>219, ≤236)3390.14 (−0.29 to +0.58)0.25 (−0.16 to +0.66)0.23 (−0.21 to +0.67)0.27 (−0.15 to +0.68)
 Fourth (>236)343−0.32 (−0.77 to +0.12)0.16 (−0.28 to +0.59)−0.16 (−0.63 to +0.31)0.12 (−0.32 to +0.56)
Arteriolar/venular ratio
 First (≤0.64)33700.0100.0600.0300.04
 Second (>0.64, ≤0.68)3470.74 (+0.30 to +1.19)0.24 (−0.17 to +0.65)0.59 (+0.15 to +1.03)0.27 (−0.15 to +0.69)
 Third (>0.68, ≤0.73)3630.62 (+0.18 to +1.06)0.09 (−0.32 to +0.50)0.36 (−0.08 to +0.80)0.13 (−0.29 to +0.54)
 Fourth (>0.73)3580.47 (+0.02 to +0.92)−0.30 (−0.72 to +0.12)0.10 (−0.35 to +0.55)−0.29 (−0.72 to +0.13)
  • Model 1 is unadjusted. Model 2 is adjusted for age, systolic BP, race, diabetes, BMI, smoking status, clinical site, and 24-hour urine protein. Model 3 is adjusted for age, systolic BP, race, diabetes, BMI, smoking status, clinical site, and eGFR. Model 4 is adjusted for age, systolic BP, race, diabetes, BMI, smoking status, clinical site, 24-hour urine protein, and eGFR.