Table 1.

Characteristics of the study groups at the initial visit (N=110)

VariablePravastatin (n=56)Placebo (n=54)P Value
Age (yr)16±416±40.50
Height (cm)165±15162±130.31
Weight (kg)66±2159±190.13
Urine microalbumin excretion (μg/min)
 Mean27±3751±1230.20
 Median12 [7, 28]11 [7, 21]0.90
Left ventricular mass index (g/m2)55±1253±100.39
Total kidney volume (ml)
 Mean571±315522±3060.41
 Median495 [349, 661]432 [329, 629]0.25
Total kidney volume corrected for height (ml/m)
 Mean336±187315±1750.55
 Median287 [213, 379]273 [204, 358]0.40
Serum creatinine (mg/dl)
 Mean0.7±0.20.6±0.10.04
 Median0.7 [0.6, 0.8]0.6 [0.5, 0.7]0.07
24-h urine creatinine clearance (ml/min per 1.73 m2)135±28138±270.66
BP (mmHg)
 Systolic 123±10122±100.44
 Diastolic 73±973±70.75
Hematocrit (%)42±440±40.03
24-h urine protein (g/d)
 Mean0.1±0.10.2±0.20.31
 Median0.11 [0.08, 0.15]0.10 [0.08, 0.16]0.68
Cholesterol (mg/dl)
 HDL49±1248±110.67
 LDL84±2390±210.23
 Total145±30151±270.26
  • Values are the mean±SD or median [25th percentile, 75th percentile]. Non-normally distributed variables were also tested with the Wilcoxon rank sum test.