Table 4.

Cox regression analysis: decompensated heart failure/death

VariableUnivariate AnalysisAdjustment for eGFR and ln AlbuminuriaAdjustment for eGFR, ln Albuminuria, Age, and SexAdjustment for eGFR, ln Albuminuria, Age, Sex, Diabetes Mellitus, and CVDAdjustment for eGFR, ln Albuminuria, Age, Sex, Diabetes Mellitus, CVD, and CKD-MBDa Variables
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P ValueHR (915% CI)P ValueHR (95% CI)P Value
ln sKlotho (pg/ml)1.12 (0.45–2.73)0.821.31 (0.53–3.21)0.561.20 (0.52–2.78)0.671.11 (0.46–2.67)0.821.01 (0.41–2.51)0.99
PTH (pg/ml)1.01 (1.00–1.01)<0.0011.00 (1.00–1.01)0.161.00 (1.00–1.01)0.111.00 (1.00–1.01)0.051.00 (1.00–1.01)0.17
FePi (%)1.04 (1.02–1.06)<0.0011.02 (1.00–1.04)0.261.01 (0.98–1.05)0.421.01 (0.98–1.04)0.501.01 (0.97–1.04)0.64
Phosphate (mg/dl)1.40 (1.06–1.84)0.021.09 (0.76–1.55)0.651.08 (0.73–1.59)0.721.14 (0.76–1.70)0.531.05 (0.64–1.72)0.84
ln FGF-23 (rU/ml)2.13 (1.66–2.72)<0.0011.86 (1.37–2.54)<0.0011.71 (1.27–2.29)<0.0011.66 (1.24–2.24)0.0011.60 (1.17–2.18)0.003
  • sKlotho (in pg/ml), albuminuria (in mg/g), and FGF-23 (in rU/ml) were ln-transferred because of skewed distribution. CVD, cardiovascular disease; CKD-MBD, CKD–mineral and bone disorders; HR, hazard ratio; 95% CI, 95% confidence interval; sKlotho, PTH, parathyroid hormone; FePi, urinary fractional phosphate excretion.

  • a Ln sKlotho, PTH, FePi, phosphate and/ or Ln FGF-23, as appropriate.