Variable | Univariate Analysis | Adjustment for eGFR and ln Albuminuria | Adjustment for eGFR, ln Albuminuria, Age, and Sex | Adjustment for eGFR, ln Albuminuria, Age, Sex, Diabetes Mellitus, and CVD | Adjustment for eGFR, ln Albuminuria, Age, Sex, Diabetes Mellitus, CVD, and CKD-MBD^{a} Variables | |||||
---|---|---|---|---|---|---|---|---|---|---|

HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (915% CI) | P Value | HR (95% CI) | P Value | |

ln sKlotho (pg/ml) | 1.12 (0.45–2.73) | 0.82 | 1.31 (0.53–3.21) | 0.56 | 1.20 (0.52–2.78) | 0.67 | 1.11 (0.46–2.67) | 0.82 | 1.01 (0.41–2.51) | 0.99 |

PTH (pg/ml) | 1.01 (1.00–1.01) | <0.001 | 1.00 (1.00–1.01) | 0.16 | 1.00 (1.00–1.01) | 0.11 | 1.00 (1.00–1.01) | 0.05 | 1.00 (1.00–1.01) | 0.17 |

FePi (%) | 1.04 (1.02–1.06) | <0.001 | 1.02 (1.00–1.04) | 0.26 | 1.01 (0.98–1.05) | 0.42 | 1.01 (0.98–1.04) | 0.50 | 1.01 (0.97–1.04) | 0.64 |

Phosphate (mg/dl) | 1.40 (1.06–1.84) | 0.02 | 1.09 (0.76–1.55) | 0.65 | 1.08 (0.73–1.59) | 0.72 | 1.14 (0.76–1.70) | 0.53 | 1.05 (0.64–1.72) | 0.84 |

ln FGF-23 (rU/ml) | 2.13 (1.66–2.72) | <0.001 | 1.86 (1.37–2.54) | <0.001 | 1.71 (1.27–2.29) | <0.001 | 1.66 (1.24–2.24) | 0.001 | 1.60 (1.17–2.18) | 0.003 |

sKlotho (in pg/ml), albuminuria (in mg/g), and FGF-23 (in rU/ml) were ln-transferred because of skewed distribution. CVD, cardiovascular disease; CKD-MBD, CKD–mineral and bone disorders; HR, hazard ratio; 95% CI, 95% confidence interval; sKlotho, PTH, parathyroid hormone; FePi, urinary fractional phosphate excretion.

↵a Ln sKlotho, PTH, FePi, phosphate and/ or Ln FGF-23, as appropriate.