Table 3.

Summary of variables measured at baseline or sample 2 that were associated with change in BNP at the P≤0.05 level

Variable and PredictorContinuous VariablesCategorical Variables
β-Coefficient (95% CI)P ValueTertile 1, n (%)Tertile 2, n (%) Tertile 3, n (%) P Value
NT-BNP-76
 CKD 3–4
  Male sex10 (60)11 (69)16 (100)0.02
  cTnT-positive  (sample 1)02 (13)7 (44)0.004
  cTnT-positive  (sample 2)02 (13)8 (50)0.001
 Dialysis
  SBP (mmHg)−0.01 (−0.02 to 0.0)0.05
  cTnT-positive  (sample 1)15 (44)11 (32)22 (65)0.03
  cTnT-positive  (sample 2)17 (50)15 (44)27 (79)<0.01
 KTR
  cTnT-positive  (sample 2)1 (4)07 (30)0.002
BNP-32
 CKD 3–4
  logCRP (mg/L)−0.21 (−0.38 to −0.03)0.02
  Statin use10 (59)4 (27)11 (69)0.05
  cTnT-positive  (sample 2)4 (24)06 (18)0.04
 Dialysis
   Heart failure11 (32)2 (6)6 (18)0.02
 KTR
  Hemoglobin  (per 10 g/dl)−0.01 (−0.01 to 0.0)0.02
  Albumin  (per 1 g/dl)−0.04 (0.07 to 0.0)0.05
  cTnT-positive  (sample 1)1 (4)05 (21)0.02
  cTnT-positive  (sample 2)1 (4)07 (30)0.002
  • The β-coefficient is the change in the natural logarithm–transformed ratio of the second to the first BNP sample for each unit change of the variable presented. Categorical variables are presented as the number (percentage) in each progressive tertile of change in BNP. Actual BNP concentrations that define tertiles are available in Supplemental Table 3. SBP, systolic BP; KTR, kidney transplant recipient; CRP, C-reactive protein; 95% CI, 95% confidence interval.