Table 2.

Creatinine changes in subgroups of patients with baseline and follow-up creatinine

Patient GroupsAll PatientsNo AKIAKI-1AKI-2AKI-3
Creatinine changes in all 700 patients
 Number of patients70024121875166
 HA0.95 (0.74–1.33)0.88 (0.71–1.18)0.92 (0.71–1.23)0.94 (0.75–1.26)1.26 (0.84–2.26)
 ICU admission0.88 (0.64–1.29)0.80 (0.63–0.98)0.81 (0.60–1.07)0.86 (0.60–1.30)1.44 (1.03–2.82)
 Peak1.28 (0.89–2.20)0.96 (0.79–1.20)1.10 (0.84–1.50)1.56 (1.14–2.00)3.92 (2.44–5.20)
 ICU discharge0.63 (0.50–0.85)0.59 (0.50–0.71)0.61 (0.48–0.76)0.66 (0.50–0.87)1.05 (0.53–2.06)
 HD0.63 (0.51–0.81)0.61 (0.50–0.75)0.61 (0.50–0.74)0.61 (0.50–0.75)0.77 (0.54–1.25)
 P value (HA versus HD)<0.001<0.001<0.001<0.001<0.001
Creatinine changes in 160 patients with premorbid BL creatinine
 Number of patients16038282470
 BL0.88 (0.73–1.11)0.81 (0.71–0.89)0.92 (0.69–1.06)0.95 (0.80–1.16)0.94 (0.76–1.21)
 HA1.05 (0.78–1.48)0.86 (0.74–1.18)0.92 (0.60–1.17)1.03 (0.83–1.45)1.24 (0.84–2.51)
 ICU admission1.11 (0.72–1.97)0.80 (0.68–0.98)0.88 (0.51–1.14)1.18 (0.63–1.50)2.07 (1.11–2.99)
 Peak1.77 (1.10–3.46)1.04 (0.83–1.26)1.11 (0.75–1.57)1.73 (1.28–2.46)3.69 (2.71–5.11)
 ICU discharge0.70 (0.49–1.37)0.61 (0.50–0.77)0.57 (0.39–0.76)0.63 (0.52–0.89)1.33 (0.58–2.24)
 HD0.72 (0.57–1.01)0.66 (0.53–0.84)0.65 (0.51–0.82)0.71 (0.63–0.89)0.86 (0.66–1.31)
 P value (BL versus HD)<0.001<0.001<0.0010.0040.14
Creatinine changes in 221 patients with FU creatinine
 Number of patients22158622378
 HA1.02 (0.76–1.47)1.01 (0.79–1.33)0.84 (0.58–1.13)0.87 (0.73–1.15)1.35 (0.99–2.44)
 ICU admission1.01 (0.63–1.56)0.88 (0.67–1.07)0.75 (0.52–1.05)0.74 (0.57–1.24)1.78 (1.11–2.92)
 Peak1.50 (0.96–2.98)1.03 (0.81–1.45)1.00 (0.74–1.47)1.48 (1.08–1.87)4.13 (2.62–5.32)
 ICU discharge0.67 (0.50–1.22)0.60 (0.52–0.74)0.56 (0.41–0.74)0.69 (0.55–0.87)1.50 (0.70–2.67)
 HD0.67 (0.53–0.90)0.64 (0.56–0.76)0.56 (0.48–0.72)0.64 (0.50–0.84)0.92 (0.67–1.47)
 FU0.85 (0.67–1.07)0.77 (0.67–0.89)0.72 (0.60–0.90)0.87 (0.64–1.10)1.04 (0.82–1.49)
 P value (HD versus FU)<0.001<0.001<0.0010.010.02
Creatinine changes in 96 patients with both BL and FU creatinine
 Number of patients9617161647
 BL0.96 (0.77–1.16)0.86 (0.74–1.02)0.92 (0.62–1.05)0.98 (0.76–1.13)1.02 (0.82–1.33)
 HA1.11 (0.80–1.49)0.84 (0.77–1.29)0.92 (0.59–1.17)0.97 (0.75–1.41)1.32 (0.94–2.51)
 ICU admission1.15 (0.68–2.20)0.80 (0.64–0.98)0.99 (0.49–1.16)0.88 (0.59–1.38)2.12 (1.14–3.13)
 Peak2.00 (1.20–3.83)1.09 (0.81–1.29)1.21 (0.72–1.69)1.52 (1.20–1.88)3.81 (2.72–4.93)
 ICU discharge0.78 (0.51–1.65)0.63 (0.51–0.85)0.53 (0.39–0.89)0.62 (0.52–0.77)1.43 (0.70–2.60)
 HD0.76 (0.55–1.09)0.67 (0.54–0.85)0.57 (0.50–0.82)0.68 (0.63–0.89)1.01 (0.70–1.67)
 FU0.96 (0.72–1.28)0.84 (0.78–0.97)0.72 (0.60–0.85)1.00 (0.81–1.31)1.12 (0.88–1.96)
 P value (BL versus HD)<0.0010.0030.010.10.4
 P value (HD versus FU)<0.0010.030.110.010.02
 P value (BL versus FU)0.10.70.20.300.01
  • Paired comparisons were by the Wilcoxon signed rank test. HA, hospital admission; ICU, intensive care unit; HD, hospital discharge; BL, baseline; FU, follow-up.