Table 4.

Adverse events during 12 months of rapamycin treatment

VariableLow-Dose Rapamycin (n=10)Standard-Dose Rapamycin (n=10)Standard Care (n=10)P Valuea
Serious adverse events (see text)121>0.99
Oral ulcerations2600.01b
Nonserious infections2650.27
Edema0120.75
Gastrointestinal symptoms1350.20
Dermatitis2000.31
Miscellaneous/other2770.05
Total adverse events1025200.09
  • a Based on Poisson model for count data.

  • b Adjusted pairwise comparisons: low dose (LD) versus standard care (SC): P=0.47; standard dose (STD) versus SC: P=0.01; LD versus STD: P=0.17; LD+STD versus SC: P=0.03.