Table 1.

Baseline characteristics and risk factors of the three groups of patients with autosomal dominant polycystic kidney disease

VariableLow-Dose Rapamycin (n=10)Standard-Dose Rapamycin (n=10)Standard Care (n=10)P Valuea
Mean age±SD (yr)44.9±8.653.2±15.049.4±11.00.31
Whites (n)10b109>0.99
Men (n)5570.72
Hypertension (BP≥140/90 mmHg before age 35 yr) (31) (n)3350.71
Family history of ESRD from ADPKD before age 56 yr (6) (n)8470.25
Initial iGFR 25–59 ml/min per 1.73 m2 (n)4320.88
Initial TKV>1500 ml (3) (n)766>0.99
Initial height-adjusted TKV≥600 ml/m (5) (n)8660.70
  • ADPKD, autosomal dominant polycystic kidney disease; iGFR, 125I-iothalamate GFR; TKV, total kidney volume.

  • a Based on ANOVA for continuous variables and Fisher exact test for categorical variables.

  • b Number in each group.