Table 1.

Recipient and allograft characteristics by preimplant biopsy-reported ATN

CharacteristicAll (N=651)ATN (n=110)No ATN (n=541)P Valuea
Recipient
 Age, yr59 (51–67)60 (50–67)59 (51–67)0.9
 Men407 (63)71 (65)336 (62)0.63
 Body mass index, kg/m228 (25–33)29 (25–33)28 (25–32)0.32
 Black race268 (41)42 (38)226 (42)0.49
 Dialysis duration, mo52 (31–71)49 (35–69)52 (31–72)0.97
 Cause of ESRD0.09
  Hypertension211 (32)25 (23)186 (34)
  Diabetes194 (30)38 (35)156 (29)
  GN94 (14)21 (19)73 (13)
  Graft failure (prior transplant)40 (6)9 (8)31 (6)
  Other112 (17)17 (15)95 (18)
 HLA mismatches5 (4–5)5 (4–6)5 (4–5)0.04
 HLA-DR mismatches0.04
  086 (13)16 (15)70 (13)
  1278 (43)35 (32)243 (45)
  2286 (44)59 (54)227 (42)
Allograft (donor)
 Age, yr51 (44–58)53 (47–60)51 (43–58)0.44
 Men407 (63)62 (56)345 (64)0.14
 Body mass index, kg/m228 (24–33)28 (24–34)28 (24–33)0.73
 Black race117 (18)13 (12)104 (19)0.23
 Hypertension338 (52)48 (44)290 (54)0.06
 Diabetes109 (17)16 (15)93 (17)0.5
 Cause of death0.16
  Head trauma126 (19)22 (20)104 (19)
  Stroke290 (45)46 (42)244 (45)
  Anoxia216 (33)42 (38)174 (32)
  Other126 (19)22 (20)104 (19)
 Hepatitis C13 (2)2 (2)11 (2)0.88
 Expanded-criteria donor243 (37)43 (39)200 (37)0.67
 Donation after cardiac death154 (24)22 (20)132 (24)0.32
 Kidney donor risk index1.44 (1.23–1.67)1.43 (1.23–1.59)1.45 (1.21–1.69)0.28
 Kidney donor profile index, %84 (70–92)83 (71–89)84 (69–92)0.27
 Admission serum creatinine, mg/dl1.0 (0.8–1.3)1.0 (0.8–1.3)1.0 (0.7–1.2)0.37
 Terminal serum creatinine, mg/dl1.0 (0.7–1.4)1.0 (0.7–1.4)1.0 (0.7–1.4)0.91
 Terminal urine output, ml/h129 (88–218)130 (87–219)126 (97–196)0.60
 Any vasoactive agent usedb550 (84)460 (85)90 (82)0.40
 Cold-ischemia time, h17 (13–22)16 (12–23)17 (13–22)0.53
 Kidney machine perfused433 (67)81 (74)352 (65)0.09
 Perfusate flow at 4 h, ml/min115 (96–130.5)116 (96–131)109 (96–129)0.28
 Renal resistance at 4 h, mmHg/ml per min0.23 (0.19–0.29)0.23 (0.18–0.29)0.25 (0.2–0.3)0.16
  • Values are the median (interquartile range) or n (%). ATN, acute tubular necrosis.

  • a P values comparing kidneys with to those without ATN by t tests for continuous variables or chi-squared tests for categorical variables.

  • b Considered “yes” if at least one of the following medications were administered as part of deceased-donor management within 24 hours of organ procurement: dopamine, epinephrine, norepinephrine, phenylephrine, arginine vasopressin, dobutamine, or sodium nitroprusside.