Table 1.

Biomarker performance for AKI prediction in noncardiopulmonary bypass pediatric ICU patients

AuthorYearNPatientsSepsis (%)AKI OutcomeBiomarkerSensitivitySpecificityPPVNPVAUC-ROC
Herrero (4)200725Foley28DetectionSerum cystatin C (0.6 mg/L)85632.3 (+LR)NR0.85
Serum β2-microglobulin (1.5 mg/L)85541.8 (+LR)NR0.82
Zappitelli (5)2007140MV Foley22.9Persistent AKI at 48 hUrinary NGAL (0.2 ng/mg creatinine)7867NRNR0.63
Urinary NGAL (0.4 ng/mg creatinine)6778NRNR
Washburn (6)2008137MV Foley21Prediction at 24 hUrinary IL-18 (100 pg/ml)258122830.54
Urinary IL-18 (200 pg/ml)13892082
Wheeler (7)2008143Sepsis100Prediction of AKI within 7 dSerum NGAL (139 ng/ml)863939940.68
Basu (24)201170Sepsis100Persistent AKI at 7 dMMP-810041241000.66
Ela-210049271000.69
  • Above are the most prominent pediatric studies examining biomarker performance for AKI in critically ill pediatric patients who were not subjected to cardiopulmonary bypass surgery. AUC-ROC, area under the curve receiver-operating characteristic; Ela-2, neutrophil elastase-2; Foley, indwelling Foley catheter; ICU, intensive care unit; +LR, positive likelihood ratio; MMP-8, matrix metalloproteinase-8; MV, mechanical ventilation; NGAL, neutrophil gelatinase-associated lipocalin; NPV, negative predictive value; NR, not reported; PPV, positive predictive value.