Table 4.

Measures of diagnostic test accuracy of early Cr elevation for severe AKI

EndpointNumber of EventsSensitivity (95% CI)Specificity (95% CI)Positive Predictive Value (95% CI)Negative Predictive Value (95% CI)Positive Likelihood Ratio (95% CI)Negative Likelihood Ratio (95% CI)Diagnostic Odds Ratio (95% CI)
Severe AKI within 7 d
 All38a0.92 (0.78 to 0.98)0.62 (0.57 to 0.66)0.16 (0.12 to 0.22)0.99 (0.97 to 1.00)2.41 (2.08 to 2.79)0.13 (0.04 to 0.38)18.8 (5.7 to 62.1)
 Very high risk161.00 (0.76 to 1.00)0.11 (0.06 to 0.20)0.17 (0.10 to 0.26)0.83 (0.74 to 0.90)1.13 (1.05 to 1.22)0 (NA)NA
 High risk120.92 (0.60 to 0.96)0.66 (0.59 to 0.73)0.14 (0.08 to 0.25)0.86 (0.75 to 0.92)2.69 (0.08 to 3.49)0.13 (0.02 to 0.83)21.3 (2.7 to 168.8)
 Moderate risk81.00 (0.60 to 1.00)0.76 (0.68 to 0.82)0.19 (0.09 to 0.34)1.00 (0.96 to 1.00)4.11 (3.08 to 5.49)0 (NA)NA
Severe AKI in ICU
 All59a0.89 (0.79 to 0.95)0.64 (0.59 to 0.68)0.25 (0.19 to 0.31)0.98 (0.95 to 0.99)2.50 (2.14 to 2.9)0.16 (0.07 to 0.34)15.7 (6.6 to 37.3)
 Very high risk211.00 (0.81 to 1.00)0.12 (0.06 to 0.21)0.22 (0.15 to 0.32)1.00 (0.66 to 1.00)1.14 (1.05 to 1.23)0 (NA)NA
 High risk260.88 (0.69 to 0.97)0.70 (0.63 to 0.76)0.30 (0.20 to 0.42)0.98 (0.93 to 0.99)2.95 (2.27 to 3.84)0.16 (0.06 to 0.48)17.9 (5.2 to 62.1)
 Moderate risk100.90 (0.54 to 0.99)0.76 (0.68 to 0.83)0.21 (0.11 to 0.36)0.99 (0.94 to 0.99)3.76 (2.63 to 5.38)0.13 (0.02 to 0.85)28.6 (3.5 to 233.8)
  • 95% CI, 95% confidence interval; NA, not applicable.

  • a Two severe AKI events occurred in the low-risk tranche (both within first 7 ICU days).