Table 3.

Associations between continuous and quartile of serum ALP and all-cause and cardiovascular mortality

Model 1aModel 2b,cModel 3c,d
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
All-cause mortality
 Baseline continuous ALPe1.05 (1.02 to 1.08)<0.001f1.03 (1.00 to 1.07)0.04f1.04 (1.00 to 1.08)0.04f
 Follow-up continuous ALPe1.09 (1.04 to 1.13)<0.001f1.08 (1.02 to 1.15)0.01f1.08 (1.01 to 1.15)0.02f
 Baseline ALP quartile 11.01.01.0
 Baseline ALP quartile 21.17 (0.75 to 1.81)0.501.18 (0.74 to 1.86)0.491.43 (0.85 to 2.41)0.18
 Baseline ALP quartile 31.38 (0.90 to 2.12)0.141.21 (0.77 to 1.89)0.421.40 (0.83 to 2.34)0.20
 Baseline ALP quartile 41.98 (1.33 to 2.93)0.001f1.67 (1.08 to 2.57)0.02f2.05 (1.24 to 3.41)0.01f
P for trend<0.001f0.02f0.01f
Cardiovascular mortality
 Baseline continuous ALPe1.07 (1.03 to 1.10)<0.001f1.06 (1.02 to 1.10)0.003f1.07 (1.02 to 1.11)0.003f
 Follow-up continuous ALPe1.08 (1.02 to 1.15)0.01f1.08 (1.00 to 1.16)0.051.08 (1.00 to 1.17)0.06
 Baseline ALP quartile 11.01.01.0
 Baseline ALP quartile 21.30 (0.71 to 2.38)0.391.39 (0.74 to 2.61)0.311.61 (0.79 to 3.29)0.19
 Baseline ALP quartile 31.35 (0.74 to 2.47)0.331.19 (0.63 to 2.26)0.591.36 (0.66 to 2.80)0.41
 Baseline ALP quartile 42.17 (1.26 to 3.74)0.01f2.03 (1.12 to 3.67)0.02f2.40 (1.20 to 4.78)0.01f
P for trend0.004f0.03f0.02f
  • HR, hazard ratio; 95% CI, 95% confidence interval.

  • a Model 1: unadjusted.

  • b Model 2: adjusted for age, sex, 24-hour urine output, BP, comorbidity score, hemoglobin, albumin, serum ALT, AST, N/L, and phosphate binders use.

  • c Additionally adjusted for physiologic calcium peritoneal dialysate use while analyzing follow-up ALP.

  • d Model 3: model 2 adjusted for corrected calcium, phosphorus, and iPTH.

  • e Per 10 U/L higher ALP.

  • f P<0.05 is considered statistically significant.