Model | NRI | IDI | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|

NRI Event | P Value | NRI Nonevent | P Value | Total NRI | P Value | IS | P Value | IP | P Value | Total IDI | P Value | |

RAI+NGAL | −0.035 | 0.85 | 0.546 | <0.001 | 0.512 | 0.01 | 0.023 | 0.13 | −0.004 | 0.32 | 0.027 | 0.08 |

RAI+MMP-8 | −0.172 | 0.35 | 0.600 | <0.001 | 0.428 | 0.03 | 0.025 | 0.30 | −0.004 | 0.15 | 0.029 | 0.23 |

RAI+Ela-2 | 0.172 | 0.35 | 0.373 | <0.001 | 0.545 | 0.01 | 0.065 | 0.07 | −0.010 | 0.05 | 0.075 | 0.03 |

RAI+NGAL+MMP-8 | 0.103 | 0.58 | 0.503 | <0.001 | 0.606 | 0.002 | 0.058 | 0.06 | −0.009 | 0.05 | 0.067 | 0.02 |

RAI+NGAL+Ela-2 | 0.379 | 0.04 | 0.492 | <0.001 | 0.871 | <0.001 | 0.086 | 0.02 | 0.014 | 0.03 | 0.100 | 0.01 |

RAI+MMP-8+Ela-2 | 0.172 | 0.35 | 0.459 | <0.001 | 0.632 | 0.002 | 0.067 | 0.06 | −0.011 | 0.04 | 0.078 | 0.02 |

The prediction model of the RAI for day 3 AKI was used as the reference model for evaluating the models incorporating biomarkers NGAL, MMP-8, and Ela-2 individually and in combination. NRI and IDI values shown represent the total effect for both events (with day 3 AKI) and nonevents (without day 3 AKI). IP, difference of integral of 1-specificity between models; IS, difference of integral of sensitivity between models.