Table 7.

Inclusion of biomarkers significantly improves discrimination of the RAI for AKI

ModelNRIIDI
NRI EventP ValueNRI NoneventP ValueTotal NRIP ValueISP ValueIPP ValueTotal IDIP Value
RAI+NGAL−0.0350.850.546<0.0010.5120.010.0230.13−0.0040.320.0270.08
RAI+MMP-8−0.1720.350.600<0.0010.4280.030.0250.30−0.0040.150.0290.23
RAI+Ela-20.1720.350.373<0.0010.5450.010.0650.07−0.0100.050.0750.03
RAI+NGAL+MMP-80.1030.580.503<0.0010.6060.0020.0580.06−0.0090.050.0670.02
RAI+NGAL+Ela-20.3790.040.492<0.0010.871<0.0010.0860.020.0140.030.1000.01
RAI+MMP-8+Ela-20.1720.350.459<0.0010.6320.0020.0670.06−0.0110.040.0780.02
  • The prediction model of the RAI for day 3 AKI was used as the reference model for evaluating the models incorporating biomarkers NGAL, MMP-8, and Ela-2 individually and in combination. NRI and IDI values shown represent the total effect for both events (with day 3 AKI) and nonevents (without day 3 AKI). IP, difference of integral of 1-specificity between models; IS, difference of integral of sensitivity between models.