Table 2.

Association of FGF-23, eGFRCrCyC, and UACR with AKI

CharacteristicQuartile
1234
FGF-23
 Range (RU/ml)<5454–7071–100>100
 Annual event rate, % (no. events/no. at risk)0.22 (18/824)0.44 (34/821)0.40 (29/807)0.67 (38/789)
 Unadjusted1.00 (ref)2.09 (1.18 to 3.70)1.81 (1.00 to 3.28)3.38 (1.91 to 5.98)
 Age, sex, race adjusted1.00 (ref)2.47 (1.39 to 4.40)2.13 (1.17 to 3.88)4.37 (2.44 to 7.83)
 Plus cardiovascular risk factorsa1.00 (ref)2.35 (1.32 to 4.19)1.79 (0.97 to 3.28)3.06 (1.67 to 5.63)
 Plus other kidney variablesb1.00 (ref)2.08 (1.16 to 3.72)1.43 (0.77 to 2.65)1.99 (1.04 to 3.80)
eGFRCrCyC
 Range (ml/min per m2)>8069–8057–68<57
 Annual event rate, % (no. events/no. at risk)0.26 (22/825)0.25 (19/820)0.49 (35/803)0.74 (41/793)
 Unadjusted1.00 (ref)0.97 (0.52 to 1.81)2.08 (1.22 to 3.54)3.47 (2.06 to 5.85)
 Age, sex, race adjusted1.00 (ref)1.00 (0.53 to 1.87)2.07 (1.20 to 3.58)3.29 (1.91 to 5.67)
 Plus cardiovascular risk factorsa1.00 (ref)1.04 (0.56 to 1.96)1.96 (1.13 to 3.41)2.71 (1.55 to 4.75)
 Plus other kidney variablesc1.00 (ref)0.96 (0.51 to 1.80)1.81 (1.04 to 3.15)2.15 (1.21 to 3.82)
UACR
 Range (mg/g)<4.74.7–8.99.0–20.9>20.9
 Annual event rate, % (no. events/no. at risk)0.20 (17/825)0.27 (21/808)0.49 (34/812)0.79 (45/796)
 Unadjusted1.00 (ref)1.52 (0.79 to 2.91)2.88 (1.59 to 5.22)5.19 (2.92 to 9.22)
 Age, sex, race adjusted1.00 (ref)1.59 (0.83 to 3.04)2.87 (1.58 to 5.21)4.80 (2.70 to 8.54)
 Plus cardiovascular risk factorsa1.00 (ref)1.48 (0.77 to 2.85)2.59 (1.42 to 4.73)3.79 (2.08 to 6.92)
 Plus other kidney variablesd1.00 (ref)1.56 (0.81 to 3.01)2.62 (1.44 to 4.79)3.35 (1.83 to 6.13)
  • Data are presented as hazard ratios (95% confidence intervals) unless otherwise indicated.

  • a Adjusted for age, sex, race, hypertension, diabetes mellitus, smoking, body mass index, prior stroke, prior heart failure, prior coronary heart disease, total cholesterol, and C-reactive protein.

  • b Further adjusted for eGFRCrCyC and UACR.

  • c Further adjusted for FGF-23 and UACR.

  • d Further adjusted for FGF-23 and eGFRCrCyC.