Table 4.

Annual rate of change in LnCRP [Ln(mg/L)] over time in various clinical strata

StratumEstimate Slopea95% Confidence IntervalP Value SlopeP Value Interaction Term
Age<65.9 yr0.120.02 to 0.220.02Age×time
Age≥65.9 yr0.06−0.04 to 0.160.260.72
Men0.150.06 to 0.240.002Sex×time
Women0.01−0.09 to 0.120.800.07
DM0.210.07 to 0.350.004DM×time
No DM0.07−0.02 to 0.150.110.12
CVD0.07−0.04 to 0.170.21CVD×time
No CVD0.120.02 to 0.220.020.52
RKF0.06−0.03 to 0.150.17
No RKF0.150.03 to 0.260.01
No RKF hemodialysis0.270.11 to 0.42<0.0010.04b
No RKF hemodiafiltration−0.01−0.18 to 0.170.930.53b
Vintage below median0.07−0.02 to 0.170.14Vintage×time
Vintage at and above median0.120.02 to 0.210.010.16
  • All analyses on strata were adjusted for age, sex, dialysis vintage, randomized group (excluding the conventional risk factor of the stratum under study), and presence of DM, CVD, and RKF. Estimates in this table may differ slightly from estimates in the text of the Results, because estimates in this table are derived from models performed in the subgroups separately. LnCRP, natural logarithm of C-reactive protein.

  • a Estimate slope indicates the mean longitudinal change per year in LnCRP levels associated with the presence or absence of the conventional risk factor, the percent change per year calculated by eΔLnCRP.

  • b Versus RKF (no difference hemodialysis and hemodiafiltration)