Table 2.

Correlation of interstitial infiltration with clinical, demographic, and cellular parameters

ParameterCD68DC-SIGNCD4 CD8CD20
Male sex−0.070.100.010.020.23a
Age (yr)0.140.19a0.020.080.09
Serum creatinine (mg/dl)0.34b0.42b0.26c0.30c0.38b
Serum uric acid (mg/dl)0.080.24c0.140.150.27c
Proteinuria (g/24 h)0.44b0.22a0.35b0.36b0.31b
Erythrocyturia (+)d0.190.120.24c0.27c0.21a
Systolic BP (mmHg)0.22a0.18a0.18a0.120.19a
Diastolic BP (mmHg)0.130.150.130.100.09
Mesangial hypercellularity0.23a0.27c0.23c0.20a0.12
Segmental glomerulosclerosis0.170.19a0.25c0.33b0.32c
Endocapillary hypercellularity0.20a0.010.010.040.03
Tubular atrophy/interstitial fibrosis0.62b0.56b0.56b0.60b0.55b
Global glomerulosclerosise0.150.150.080.17a0.17
Crescentsf0.180.22a0.25c0.18a0.13
Arterial wall thickening0.37b0.36b0.40b0.42b0.39b
Arterial hyalinosisf0.29c0.22c0.21a0.24c0.35b
CD68+0.43b0.53b0.49b0.54b
DC-SIGN+0.43b0.62b0.60b0.62b
CD4+0.53b0.62b0.79b0.70b
CD8+0.49b0.60b0.79b0.69b
CD20+0.54b0.62b0.70b0.69b
  • Data are presented as Spearman’s correlation coefficients. Values of the respective cell types are presented as the number of cells per millimeter squared. RBC, red blood cell; HPF, high-power cortical field.

  • a P<0.05.

  • b P<0.001.

  • c P<0.01.

  • d The severity of erythrocyturia was characterized as follows: 3 ≤ RBC ≤ 5/HPF was defined as 1+; 5 <RBC ≤ 20/HPF as 2+; 20 < RBC ≤ 50 RBC/HPF as 3+; and >50 RBC/HPF as 4+. Pathologic features were scored using the Oxford classification (8,9).

  • e The severity of global glomerulosclerosis and arterial wall thickening was graded in three groups: normal, mild, and marked.

  • f Crescents and arterial hyalinosis were scored as either present or absent.