Table 4.

Differences in clinical, demographic, cellular, and tertiary lymphoid organ parameters between patients with good and poor outcomes

ParameterSevere GroupStable GroupP Value
Patients (n)1260
Male sex (%)58.3500.60
Age (yr)37.5 (27.5–50.8)35.0 (27.0–44.0)0.25
Serum creatinine (mg/dl)1.5 (1.1–2.5)0.9 (0.6–1.1)<0.001
Serum uric acid (mg/dl)6.8 (5.8–8.2)5.5 (4.5–6.9)0.01
Proteinuria (g/24 h)2.1 (1.2–4.1)1.0 (0.5–1.6)0.01
BP (mmHg)
 Systolic 126.0 (109.0–157.0)125.5 (117.5–138.8)0.97
 Diastolic 81.5 (72.3–94.0)80.0 (72.3–89.8)0.82
Oxford classificationc
 M1 91.755.00.02
 S1 66.738.30.07
 T2 91.716.7<0.001
Marked global glomerulosclerosisd33.310.00.03
Presence of crescentse25.013.30.31
Marked arterial wall thickening66.713.3<0.001
Presence of arterial hyalinosis66.725.00.05
CD68+216.7 (136.9–371.7)79.2 (39.5–146.6)0.001
DC-SIGN+ 126.3 (32.7–143.1)29.2 (12.5–67.1)0.002
CD4+395.8 (221.5–633.3)142.3 (75.8–275.8)<0.001
CD8+164.0 (98.6–250.0)73.5 (41.8–135.6)0.001
CD20+180.4 (55.7–329.3)43.8 (11.9–83.3)0.01
Presence of TLOs83.333.30.001
  • Data are presented as a percentage or as the median (25th–75th percentile). Comparisons between the groups were performed by chi-squared tests or nonparametric tests. Values of the respective cell types are presented as the number of cells per millimeter squared.

  • a The severity of erythrocyturia was defined as follows: 3≤RBCs≤ 5/HPF was defined as 1+; 5<RBCs ≤ 20/HPF as 2+; 20<RBCs ≤ 50 red blood cells/HPF as 3+; and >50 RBCs/HPF as 4+.

  • b Follow-up data.

  • c Pathologic features were scored using Oxford classification (8,9). M1 was defined by the presence of >3 cells in the most cellular mesangial area, but not adjacent to the vascular stalk, on >50% of the glomeruli. S1 was defined by the presence of tuft adhesion and segmental sclerosis but not global sclerosis. E1 was defined by the presence of an increased number of cells within the capillary lumina causing narrowing. The percentage of cortical area damaged by interstitial fibrosis or tubular atrophy was defined as T0 (≤25%), T1 (26%–50%), or T2 (>50%).

  • d The severity of global glomerulosclerosis and arterial wall thickening was divided into three groups: normal, mild, and marked.

  • e Crescents and arterial hyalinosis were scored as present or absent.