Table 3.

Predictors of ESRD in C3 glomerulopathy

FeaturenHazard Ratio95% Confidence IntervalP Value
Univariate analysis
 Features at presentation
  Age >16 yr702.690.97 to 7.460.06
  Male sex700.880.36 to 2.140.78
  Steroid treatment670.810.31 to 2.120.66
  Other immunosuppressive treatment 671.590.50 to 5.050.43
  Serum creatinine >1.5 mg/dl695.681.89 to 17.070.002
  Proteinuria >3.5 g/24 h681.770.72 to 4.370.22
  Low serum C3610.530.20 to 1.430.21
 Biopsy features 70
  DDD by EM1.520.62 to 3.750.36
  Crescentic GN2.041.10 to 3.780.02
  Arteriolar hyaline1.911.15 to 3.150.01
  Interstitial fibrosis0.980.47 to 2.030.96
Multivariate analysis69
 Age >16 yr5.451.12 to 26.50.04
 Male sex0.590.21 to 1.680.32
 Serum creatinine >1.5 mg/dl2.490.52 to 11.90.26
 DDD by EM4.701.22 to 18.10.03
 Crescentic GN2.871.34 to 6.120.01
 Arteriolar hyaline1.330.56 to 3.190.52
  • n is <70 if patients were excluded from analysis due to lack of clinical information. DDD, dense deposit disease; EM, electron microscopy.